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Cardiovascular Disease

Cellular and Molecular Mechanisms, Prevention, and Treatment

  • Book
  • © 1995

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Editors:
  1. Linda L. Gallo

    1. The George Washington University Medical Center, USA

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Atherogenesis

    1. Lipid Accumulation and Plaque Disruption: Processes Triggering Clinical Instability in Coronary Disease

      • B. Greg Brown, Xue Qiao Zhao, Drew Poulin, John J. Albers
      Pages 1-9

    2. Expression of 92 KDA Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture

      • David L. Brown, Margaret S. Hibbs, Marianne Kearney, Eric J. Topol, Jeffrey M. Isner
      Pages 11-17

    3. Proteinases and Restenosis: Matrix Metalloproteinase and their Inhibitor and Activator

      • Suresh C. Tyagi, Larry Meyer, Richard A. Schmaltz, Hanumanth K. Reddy, Donald J. Voelker
      Pages 19-30

  3. Atherogenic Lipoproteins

    1. Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis

      • H. Bryan Brewer Jr.
      Pages 31-40

    2. Homeostasis of Lipid Oxidation in the Artery Wall

      • Alan M. Fogelman, Judith A. Berliner, Mahamad Navab, Ali Andalibi, Feng Liao, Linda L. Demer et al.
      Pages 41-43

    3. Molecular Basis for the Lysine Binding Polymorphism of Lipoprotein(a)

      • Angelo M. Scanu, Ditta Pfaffinger, Olga Klezovitch, Celina Edelstein
      Pages 45-47

    4. Triglyceride-Rich Lipoprotein Metabolism and Diabetes

      • George Steiner, Gary F. Lewis
      Pages 49-55

    5. Apolipoprotein E: Paradoxes Abound

      • William R. Hazzard, Deborah Applebaum-Bowden, James G. Terry
      Pages 57-66

    6. The Role of Second Messenger Pathways in the Pathophysiology of Hyperapob and Premature Coronary Artery Disease

      • Peter O. Kwiterovich Jr., Mahnaz Motevalli
      Pages 67-73

  4. Anti-Atherogenesis/Cholesterol Removal Mechanisms

    1. The Role of HDL Receptors in Removal of Cellular Cholesterol

      • John F. Oram, Armando J. Mendez, Gordon A. Francis, Edwin L. Bierman
      Pages 75-78

    2. The Defect in HDL3 Mediated Efflux of Newly Synthesized Cholesterol is Associated with Impaired Activation of Protein Kinase C in Tangier Fibroblasts

      • Gerd Schmitz, Gerhard Rogler, Wolfgang Drobnik, Barbara Trümbach, Christoph Moellers, Karl J. Lackner
      Pages 79-87

    3. Cholesterol Efflux from Cells in Culture: Studies with Lipid-Free Acceptors, Reconstituted Particles and Whole Serum

      • G. H. Rothblat, P. Yancey, W. S. Davidson, V. Atger, S. Lund-Katz, W. J. Johnson et al.
      Pages 89-95

    4. Apo A-I Containing Particles and Atherosclerosis

      • Jean-Charles Fruchart, Graciela Castro, Patrick Duriez
      Pages 97-103

  5. Signal Transduction in Vascular Proliferation

    1. Vascular Endothelium: An Integrator of Pathophysiologic Stimuli in Cardiovascular Disease

      • Michael A. Gimbrone Jr.
      Pages 105-107

    2. Identification of FGF-1-Inducible Genes by Differential Display

      • Jeffrey A. Winkles, Patrick J. Donohue, Debbie K. W. Hsu, Yan Guo, Gregory F. Alberts, Kimberly A. Peifley
      Pages 109-120

    3. Antioxidants and Endothelial Expression of Vcam-1: A Molecular Paradigm for Atherosclerosis

      • Russell M. Medford
      Pages 121-127

    4. Mechanisms of Potentiation of Pdgf in Atherosclerosis

      • Xin-Hua Lin, Zhao-Yi Wang, Hyeong Reh Kim, Thomas F. Deuel
      Pages 129-132

    5. The Regulation of Normal and Pathological Angiogenesis by Vascular Endothelial Growth Factor

      • Napoleone Ferrara, John E. Park, Claire E. Walder, Stuart Bunting, G. Roger Thomas
      Pages 133-144

    6. Developmentally Associated Gene Expression in Rabbit Vascular Smooth Muscle CeLLS

      • David K. M. Han, Gene Liau
      Pages 145-151
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Keywords

About this book

The Fourteenth Washington International Spring Symposium, held in Washington, D.C., in June 1994, brought together over 400 leading scientists from 21 countries to review and update research on cardiovascular disease. This group satisfied the symposium goals of formulating a more comprehensive and integrated picture of the events contributing to atherosclerosis and of exploring modified gene expression as an to understanding the causes of atherosclerosis and providing clues to the approach prevention and treatment. This volume contains most of the papers presented at the eight plenary sessions together with selected contributions from the special sessions. The multidisciplinary nature of the chapters and their authors should stimulate the interests of biochemists, cell and molecular biologists, pathologists, pharmacologists, epidemiologists, nutritionists, and clinicians. The volume is divided into eight sections which reflect the focus of the plenary sessions. Part I focuses on the pathophysiology of atherosclerotic plaques and predicts that the nature of the fibrous cap of atheroma determines plaque disruption and clinical events. Papers in Part II deal with atherogenic lipoproteins. The introductory paper reviews the current view of the role of plasma lipoproteins in atherosclerosis. With respect to the newer members on the list,: [oxidized LDL, Lp(a)] evidence is provided that suggests the involvement of one major gene in the development of oxidized LDL lipids. the expression of inflammatory genes, and the development of aortic fatty streaks.

Editors and Affiliations

  • The George Washington University Medical Center, USA

    Linda L. Gallo

Bibliographic Information

  • Book Title: Cardiovascular Disease

  • Book Subtitle: Cellular and Molecular Mechanisms, Prevention, and Treatment

  • Editors: Linda L. Gallo

  • Series Title: Gwumc Department of Biochemistry and Molecular Biology Annual Spring Symposia

  • DOI: https://doi.org/10.1007/978-1-4615-1959-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1995

  • Hardcover ISBN: 978-0-306-44992-5Published: 30 April 1995

  • Softcover ISBN: 978-1-4613-5805-3Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1959-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 366

  • Topics: Cardiology, Biochemistry, general

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