Degenerative Diseases of the Retina

1. Front Matter

   Pages i-xv

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2. Apoptosis in Retinitis Pigmentosa

   • Zong-Yi Li, Ann H. Milam

   Pages 1-8

3. Oxidative Damage and Responses in Retinal Nuclei Arising from Intense Light Exposure

   • D. T. Organisciak, R. K. Kutty, M. Leffak, P. Wong, S. Messing, B. Wiggert et al.

   Pages 9-17

4. Light-Induced Apoptosis in the Rat Retina in Vivo

   • Charlotte E. Remé, Michael Weller, Piotr Szczesny, Kurt Munz, Farhad Hafezi, Jörg-Joachim Reinboth et al.

   Pages 19-25

5. Inhibitory Effects of Cycloheximide and Flunarizine on Light-Induced Apoptosis of Photoreceptor Cells

   • Suhui Li, Cheng-Jong Chang, Andrew S. Abler, Mark O. M. Tso

   Pages 27-38

6. Apoptosis of Photoreceptors and Lens Fiber Cells with Cataract and Multiple Tumor Formation in the Eyes of Transgenic Mice Lacking the P53 Gene and Expressing the HPV 16 E7 Gene Under the Control of the IRBP Promoter

   • David S. Papermaster, Kim Howes, Nancy Ransom, Jolene J. Windle

   Pages 39-49

7. Function, Age-Related Expression and Molecular Characterization of PEDF, A Neurotrophic Serpin Secreted by Human RPE Cells

   • Joyce Tombran-Tink

   Pages 51-60

8. Nitric Oxide in the Retina

   • O. Goureau, F. Becquet, Y. Courtois

   Pages 61-68

9. In Vitro Expression of Epidermal Growth Factor Receptor by Human Retinal Pigment Epithelial Cells

   • Yusuf K. Durlu, Makoto Tamai

   Pages 69-76

10. New Retinal Degenerations in the Mouse

    • Thomas H. Roderick, Bo Chang, Norman L. Hawes, John R. Heckenlively

    Pages 77-85

11. Chorioretinal Interface

    • P. M. Leuenberger, Y. Gambazzi, E. Rungger-Brändle

    Pages 87-94

12. Fractionation of Interphotoreceptor Matrix Metalloproteinases

    • James J. Plantner, Timothy A. Quinn, George J. Dwyer

    Pages 95-103

13. Peptides from Rhodopsin Induce Experimental Autoimmune Uveoretinitis in Lewis Rats

    • Grazyna Adamus, Henry Ortega, Lundy Campbell, Anatol Arendt, Paul A. Hargrave

    Pages 105-110

14. Retinal Degeneration in Rats Induced by Vitamin E Deficiency

    • E. El-Hifnawi, H.-J. Hettlich, C. Falk

    Pages 111-118

15. Retinal Pigment Epithelial Cells Cultured From RCS Rats Express an Increased Membrane Conductance for Calcium Compared to Normal Rats

    • O. Strauß, M. Wienrich

    Pages 119-127

16. Effect of Sugars on Photoreceptor Outer Segment Assembly

    • Monica M. Stiemke, Joe G. Hollyfield

    Pages 129-137

17. Regulatory Influences on the Glycosylation of Rhodopsin By Human and Bovine Retinas

    • Edward L. Kean, Jermin Ju, Naiqian Niu

    Pages 139-147

18. The Dolichol Pathway in the Retinal Pigment Epithelium of the Embryonic Chick

    • Edward L. Kean, Naiqian Niu

    Pages 149-154

19. Morphological and Biochemical Studies of the Retinal Degeneration in the Vitiligo Mouse

    • Sylvia B. Smith, Barbara N. Wiggert

    Pages 155-162

20. Immunological Aspects of Retinal Transplantation in Retinal Degeneration Rodents

    • Luke Qi Jiang, Duco Hamasaki, Jessica Zuletta, Marianela Jorquera

    Pages 163-175

In 1984, we organized a two-day symposium on retinal degenerations as part of the biennial meeting of the VI International Society for Eye Research, held in Alicante, Spain. The success of this first meeting led to the second held, two years later in Sendai, Japan, organized as a satellite of the VII ISER. We were fortunate that these meetings began at a time of vigorous research activity in the area of retinal degenerations, thanks to the financial support of the Retinitis Pigmentosa Foundation and the strong encouragement of its scientific director, Dr. Alan Laties. Significant advances were made so that every two years scientists were eager to meet to share their findings. The programs included presentations by both basic and clinical researchers with ample time for informal discussions in a relaxed atmos­ phere. Many investigators met for the first time at these symposia and a number of fruitful collaborations were established. This book contains the proceedings of the VI International Symposium on Retinal Degenerations held November 6-10, 1994, in Jerusalem. As with the other meetings, some new areas were covered. One session was devoted to apoptosis, an important process involved in cell death in inherited retinal degenerations. Another session was on invertebrate photoreceptors, where numerous mutations have now been identified that lead to altered function or degeneration of the retina. All participants were invited to submit chapters and most complied. We thank them for their contributions.

• clinical research
• cytokine
• cytokines
• death
• eye
• growth
• lead
• mutation
• phenotype
• receptor
• research
• retina

• University of Oklahoma Health Sciences Center, Oklahoma City, USA

  Robert E. Anderson

• University of California, San Francisco, San Francisco, USA

  Matthew M. LaVail

• The Cleveland Clinic Foundation, Cleveland, USA

  Joe G. Hollyfield

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