Skip to main content
SpringerLink
Log in
Book cover

Molecular and Subcellular Cardiology

Effects of Structure and Function

  • Book
  • © 1995

Overview

Editors:
  1. Samuel Sideman

    1. Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Rafael Beyar

    1. Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 382)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (32 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. Molecular Mechanisms of Membrane Excitability

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Ion Channels and Pumps in Cardiac Function

      • Harry A. Fozzard, Gregory Lipkind
      Pages 3-10

    3. Molecular Mechanisms of K+ Channel Blockade: 4-Aminopyridine Interaction with a Cloned Cardiac Transient K+ (Kv1.4) Channel

      • Randall L. Rasmusson, Ying Zhang, Donald L. Campbell, Mary B. Comer, Robert C. Castellino, Shuguang Liu et al.
      Pages 11-22

    4. Na+, K+-ATPase and Heart Excitability

      • David Lichtstein
      Pages 23-30

    5. Excitation-Contraction Coupling in Ventricular Myocytes: Effects of Angiotensin II

      • William H. Barry, Hiroshi Matsui, John H. B. Bridge, Kenneth W. Spitzer
      Pages 31-39

    6. Prospects for Genetic Manipulation of Cardiac Excitability

      • John H. Lawrence, David C. Johns, Nipavan Chiamvimonvat, H. Bradley Nuss, Eduardo Marban
      Pages 41-48

    7. Integrative Models and Responses in Cardiac Ischemia

      • Simon Horner, Max J. Lab
      Pages 49-60

    8. Rich Dynamics in a Simplified Excitable System

      • Shimon Marom, Amir Toib, Erez Braun
      Pages 61-66

    9. Model Studies of Cellular Excitation

      • Yoram Rudy
      Pages 67-77

  3. Intracellular Calcium and Muscle Function: SR and Filaments

    1. Front Matter

      Pages 79-79
      Download chapter PDF

    2. Confocal Microscopy Reveals Local SR Calcium Release in Voltage-Clamped Cardiac Cells

      • Withrow Gil Wier
      Pages 81-88

    3. Signaling of Ca2+ Release and Contraction in Cardiac Myocytes

      • Martin Morad
      Pages 89-96

    4. A Model of Ca2+ Release from the Sarcoplasmic Reticulum

      • Arkady Glukhovsky, Giora Amitzur, Dan Adam, Samuel Sideman
      Pages 97-108

    5. Troponin C — Troponin I Interactions and Molecular Signalling in Cardiac Myofilaments

      • R. John Solaro
      Pages 109-115

    6. The GATA-4 Transcription Factor Transactivates the Cardiac-Specific Troponin C Promoter-Enhancer in Non-Muscle Cells

      • S. Ip, David B. Wilson, Markku Heikinheimo, Jeffrey M. Leiden, Michael S. Parmacek
      Pages 117-124

    7. Sarcomere Function and Crossbridge Cycling

      • Henk E. D. J. ter Keurs
      Pages 125-135

    8. Crossbridge Dynamics in Muscle Contraction

      • Amir Landesberg, Rafael Beyar, Samuel Sideman
      Pages 137-153

    9. Mechanisms of the Frank-Starling Phenomena Studied in Intact Hearts

      • Daniel Burkhoff, Richard A. Stennett, Kazuhide Ogino
      Pages 155-161

  4. Molecular Manifestations of Cell Adaptation

    1. Front Matter

      Pages 163-163
      Download chapter PDF
Back to top

Keywords

About this book

The Henry Goldberg Workshops were set up to address the following goals: (1) To foster interdisciplinary interaction between scientists and cardiologists, identify missing links, and catalyze new ideas. (2) To relate basic microscale phenomena to the global, clinically manifested cardiac function. (3) To relate conceptual modeling and quantitative analysis to experimental and clinical data. (4) To encourage international cooperation so as to disperse medical and technological knowhow and lead to better understanding of the cardiac system. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between cardiac mechanics, electrical activation, perfusion, and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects. The third Goldberg Workshop, held in the USA at Rutgers University in 1986, highlighted the transformation of the microscale activation phenomena to macroscale activity and performance, relating electrophysiology, energy metabolism, and cardiac mechanics. The fourth Goldberg Workshop, in 1987, continued the effort to elucidate the interactions among the various parameters affecting cardiac performance, with emphasis on the ischemic heart. The fifth Workshop, held in Cambridge, UK, in 1988, dwelt on the effects of inhomogeneity of the cardiac muscle on its performance in health and disease. The sixth Workshop highlighted the role of new modem imaging techniques, that allow us to gain more insight into local and global cardiac performance in cardiac research and clinical practice.

Editors and Affiliations

  • Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

    Samuel Sideman, Rafael Beyar

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation