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Blood-Brain Barrier

Drug Delivery and Brain Pathology

  • Book
  • © 2001

Overview

Editors:
  1. David Kobiler

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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  2. Shlomo Lustig

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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  3. Shlomo Shapira

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xii
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  2. Overview of the Structure and Function of the Blood-Brain Barrier in vivo

    • Joseph D. Fenstermacher, Tavarekere Nagaraja, Kenneth R. Davies
    Pages 1-7

  3. Expression and Modulation of Blood-brain Monocarboxylate Transporters

    • Lester R. Drewes, David Z. Gerhart, Richard L. Leino, Bradley E. Enerson
    Pages 9-17

  4. Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces

    • Jean-François Ghersi-Egea, Nathalie Strazielle, Marie-Françoise Belin
    Pages 19-25

  5. Measurement and Prediction of Blood-Brain Barrier Permeability

    • N. Joan Abbott, Andreas Reichel, Mansoor Chishty, Kevin D. Read, Janet A. Taylor, David J. Begley
    Pages 27-44

  6. Recent Advances in the Development of Cell Culture Models for the Blood-Brain- and Blood-CSF-Barrier

    • Thorsten Nitz, Tanja Eisenblätter, Matthias Haselbach, Hans-Joachim Galla
    Pages 45-62

  7. Gene Expression Changes and Progression to a BBB Phenotype in a Dynamic Model of the BBB

    • Shailesh Y. Desai, Mark A. McAllister, Kristine Goodrich, Marc M. Mayberg, Damir Janigro
    Pages 63-70

  8. Novel Endothelial-Mediated Responses Associated with Microcirculation and BBB Function

    • M. Spatz, Y. Chen, J. Bembry, F. A. Lenz, E. Shohami, Raphael Mechoulam et al.
    Pages 71-82

  9. Modulators of Blood-Brain Barrier (BBB) Permeability: In Vitro and in Vivo Drug Transport to the Brain

    • A. G. De Boer, P. J. Gaillard, I. C. J. Van Der Sandt, E. C. M. De Lange, D. D. Breimer
    Pages 83-97

  10. Controlled Modulation of the Blood-Brain and Blood-Tumor Barrier Using Novel Lipid Mimetic Compounds

    • Michael Polyak, Oran Ayalon, Marina Vinnikova, Itzchak Angel, Alex Kozak
    Pages 99-112

  11. Carbon Dioxide Gas as an Angiographic Contrast Agent in the Cerebral Circulation

    • Alan J. Wilson, Miriam M. Boxer
    Pages 113-122

  12. Diffusion MRI and Q-Space Diffusion MRI: From Cerebral Ischemia to Multiple Sclerosis and Beyond

    • Yoram Cohen, Yaniv Assaf, Revital Nossin-Manor, Inbal E. Biton
    Pages 123-145

  13. Brain Iron Uptake and Transport in Animal Model of Iron Deficiency, Tardive Dyskinesia and Neurodegenerative Diseases

    • M. B. H. Youdim, K. L. Leenders, D. Ben-Shachar
    Pages 147-156

  14. Stress, Pyridostigmine and the Blood Brain Barrier

    • E. Grauer
    Pages 157-168

  15. Transcytosis and Signalling of Pneumococci at the Blood Brain Barrier

    • Joerg R. Weber, Elaine I. Tuomanen
    Pages 169-176

  16. Entry of Viruses into the Central Nervous System

    • John K. Fazakerley
    Pages 177-190

  17. An Animal Model for the Study of BBB Modulators

    • David Kobiler, David Ben-Nathan, Charles M. Rice, Paula Schneider, Menachem Halevy, Shlomo Lustig
    Pages 191-204

  18. Physiological Pathways Responsible for the Breakdown of the Blood Brain Barrier during Viral Encephalitis

    • Carol Shoshkes Reiss, Nannan Chen
    Pages 205-216

  19. Gene Transfer to the Salivary Glands: Applications in Gene Therapy

    • Ela Shai, Amos Panet, Haya Falk, Aaron Palmon
    Pages 217-225

  20. The Effect of Hyperosmotic Blood Brain Barrier Disruption on Experimental Autoimmune Encephalomyelitis

    • Haim Ovadia, Oded Abramsky, Anna Itzik, Tali Siegal
    Pages 227-231
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Keywords

About this book

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

Editors and Affiliations

  • Israel Institute for Biological Research, Ness-Ziona, Israel

    David Kobiler, Shlomo Lustig, Shlomo Shapira

Bibliographic Information

  • Book Title: Blood-Brain Barrier

  • Book Subtitle: Drug Delivery and Brain Pathology

  • Editors: David Kobiler, Shlomo Lustig, Shlomo Shapira

  • DOI: https://doi.org/10.1007/978-1-4615-0579-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-306-46708-0Published: 28 February 2002

  • Softcover ISBN: 978-1-4613-5141-2Published: 05 November 2012

  • eBook ISBN: 978-1-4615-0579-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 434

  • Topics: Neurology, Neurosciences, Veterinary Medicine/Veterinary Science, Pathology

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