Genes, Development and Cancer

1. Front Matter

   Pages i-xvi

   PDF

2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. E. B. Lewis and His Science

      • Howard D. Lipshitz

      Pages 3-9

3. Genes

   1. Front Matter

      Pages 11-11

      PDF

   2. Lewis and the Nature of the Gene

      • Howard D. Lipshitz

      Pages 13-29

   3. Star-Recessive, A Spontaneous Mutation in Drosophila Melanogaster

      • Edward B. Lewis

      Pages 31-34

   4. Another Case of Unequal Crossing-Over in Drosophila Melanogaster

      • E. B. Lewis

      Pages 35-38

   5. The Relation of Repeats to Position Effect in Drosophila Melanogaster

      • E. B. Lewis

      Pages 39-67

   6. The Pseudoallelism of White and Apricot in Drosophila Melanogaster

      • E. B. Lewis

      Pages 69-76

   7. Pseudoallelism and Gene Evolution

      • E. B. Lewis

      Pages 77-98

   8. The Theory and Application of a New Method of Detecting Chromosomal Rearrangements in Drosophila Melanogaster

      • E. B. Lewis

      Pages 99-112

   9. Some Aspects of Position Pseudoallelism

      • E. B. Lewis

      Pages 113-128

   10. Genes and Gene Complexes

       • E. B. Lewis

       Pages 129-153

4. Genes and Development

   1. Front Matter

      Pages 155-155

      PDF

   2. Lewis and the Genetic Control of Development

      • Howard D. Lipshitz

      Pages 157-174

   3. Genes and Developmental Pathways

      • E. B. Lewis

      Pages 175-203

   4. A Gene Complex Controlling Segmentation in Drosophila

      • E. B. Lewis

      Pages 205-217

   5. Genetic Control of Body Segment Differentiation in Drosophila

      • Ian Duncan, E. B. Lewis

      Pages 219-237

   6. Control of Body Segment Differentiation in Drosophila by the Bithorax Gene Complex

      • E. B. Lewis

      Pages 239-253

   7. Regulation of the Genes of the Bithorax Complex in Drosophila

      • E. B. Lewis

      Pages 255-272

While Edward B. (‘Ed’) Lewis is famous for his contributions to genetics anddev- opmental biology y, few have read his research papers. One reason for this is availability, man ny having been published in obscure journalsor as book chapters. A second is because his papers in those ?elds are very dif?cult to read. The dif?culty derives from the fact that Lewis has published infrequently, thus manypapers are condensed reviews of man nyyears’ work presented largely in summary form rather than in detail. It is not unusual for the reader to have to infer the experimental methods, even the results, from a few sentences. Furthermore, he often presents his results in terms of abstract models; thus it can be dif?cult to separate the data from the models. Ama ajor goal of this book is to make Lewis’ keypapers accessible to researchers and students. The papers are grouped into several sections that re?ect the changing focus of his research. Each section is preceded by commentary designed to place the papers in historical perspective, with respect to Lewis’ own ideas as well as to those of the larger scienti?c community. The commentaries attempt to highlight the key methods and results—as well as the signi?cance—of each paper by explaining the science in terms that should be understandable to upper-level undergraduates, graduate students and professional researchers.

• biology
• cancer
• cancer research
• genes
• genetics
• leukemia
• population

• Program in Developmental Biology, The Hospital for Sick Children Research Institute, Toronto, Canada

  Howard D. Lipshitz

• University of Toronto, Toronto, Canada

  Howard D. Lipshitz

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