Aminopeptidases in Biology and Disease

1. Front Matter

   Pages i-xix

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2. The Puromycin-Sensitive Aminopeptidase

   • Michael W. Thompson, Louis B. Hersh

   Pages 1-15

3. Methionine Aminopeptidase

   • Joseph A. Vetro, Benjamin Dummitt, Yie-Hwa Chang

   Pages 17-44

4. Placental Leucine Aminopeptidase

   • Seiji Nomura, Tomomi Ito, Shigehiko Mizutani

   Pages 45-59

5. Insulin-Regulated Aminopeptidase

   • Siew Yeen Chai, Ruani Fernando, Siying Ye, Grantley R. Peck, Anthony L. Albiston

   Pages 61-81

6. Leukotriene A4 Hydrolase

   • Fredrik Tholander, Anders Wetterholm, Jesper Z. Haeggström

   Pages 83-112

7. Arginyl Aminopeptidase

   • Sandrine Cadel, Christophe Piesse, Cécile Gouzy-Darmon, Paul Cohen, Thierry Foulon

   Pages 113-126

8. TRH-Degrading Aminopeptidase

   • Karl Bauer

   Pages 127-143

9. ERAP1 and MHC Class I Antigen Presentation

   • Tomo Saric, Alfred L. Goldberg

   Pages 145-178

10. CD13/Aminopeptidase N in Tumor Growth and Angiogenesis

    • Nenad Petrovic, Wolfgang Schacke, Linda H. Shapiro

    Pages 179-200

11. Alanyl-Aminopeptidases in Human T Cells

    • Uwe Lendeckel, Alicja Bukowska, Jens Holger Lättig, Wolfgang Brandt

    Pages 201-227

12. Aminopeptidase Inhibitors as Anti-Hypertensive Drugs

    • Xavier Iturrioz, Annabelle Reaux, Le Goazigo, Catherine Llorens-Cortes

    Pages 229-250

13. Aminopeptidase P and Vasoactive Peptides

    • Giuseppe Molinaro, Guy Boileau, Albert Adam

    Pages 251-269

14. Effects on Mammals of the Aminopeptidase Inhibitor Bestatin

    • Oscar A. Scornik, Violeta Botbol

    Pages 271-307

15. Nematode Aminopeptidases

    • Darren R. Brooks, R. Elwyn Isaac

    Pages 309-329

16. Back Matter

    Pages 331-336

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Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.

• biology
• neuropeptides
• protein
• tumor

• University of Leeds, Leeds, UK

  Nigel M. Hooper

• Otto-von-Guericke University, Magdeburg, Germany

  Uwe Lendeckel

Nigel Hooper is Professor of Biochemistry in the School of Biochemistry and Molecular Biology at the University of Leeds, UK. He received his Ph.D in 1984 from the University of Leeds with a thesis on the "Metabolism of Neuropeptides by Cell-surface Peptidases" which stimulated his interest in proteases and paved the way for much of his subsequent research. He currently co-leads the Proteolysis Research Group at Leeds and among other topics, continues to study the structure and function of several cell-surface proteases, with a particular interest in their mode of attachment to the membrane. He has published over 90 research papers, edited 4 books and co-authored the widely acclaimed undergraduate textbook Instant Notes Biochemistry. Uwe Lendeckel is a Reader at the Institute of Experimental Internal Medicine at the Otto-von-Guericke University of Magdeburg, Germany. After his study of pharmacology and toxicology he received his Ph.D in biochemistry in 1990 from the Ernst-Moritz-Arndt University of Greifswald. His thesis on the "expression of the pro-opiomelanocortin gene in rat Islets of Langerhans and other tissues" stimulated his interest in the neuro-immunological cross-talk and the regulatory roles of cell surface proteases therein. In 1989 he joined the ectopeptidase research group at the University of Magdeburg and since then continues to study regulation of expression and the function of T cell ectopeptidases in the normal and pathological immune response, with special focus on the membrane alanyl-aminopeptidase. He has published over 40 research papers.

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