Functional Aspects of the Normal, Hypertrophied, and Failing Heart

1. Front Matter

   Pages i-xviii

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2. Role of Mechanical Factors in the Regulation of Coronary Blood Flow in Normal and Failing Hearts

   1. Front Matter

      Pages 1-3

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   2. Capillary Myocyte Relationships in the Ventricular Wall

      • James B. Caulfield, Sun Ben Tao

      Pages 4-15

   3. Role of Mechanical Factors in Coronary Inflow

      • Francis L. Abel

      Pages 16-39

   4. Evolving Concepts of Coronary Pressure-Flow Relationships

      • Francis J. Klocke, John M. Canty Jr., Robert E. Mates

      Pages 40-56

   5. Transmural Flow During Physiological Vasodilation

      • H. Fred Downey

      Pages 57-70

   6. Regulation of Coronary Blood Flow in the Underperfused Ventricle

      • Douglas M. Griggs Jr.

      Pages 71-85

3. Vascular Smooth Muscle

   1. Front Matter

      Pages 87-87

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   2. Excitation, Contraction and the Distribution of Calcium and Sodium in Smooth Muscle

      • A. P. Somlyo, A. V. Somlyo, M. Bond, T. Kitazawa, H. Shuman, A. J. Wasserman

      Pages 89-102

   3. Role of the Na+ Pump in Vascular Smooth Muscle Contractility

      • Julius C. Allen, Richard D. Bukoski, Stephen S. Navran, Charles L. Seidel

      Pages 103-117

   4. Regulation of Myosin Phosphorylation in Smooth Muscle

      • J. T. Stull, J. R. Miller, P. J. Silver

      Pages 118-134

   5. Autonomic Nerves, Aggregating Platelets and Contraction of Coronary Arterial Smooth Muscle

      • P. M. Vanhoutte

      Pages 135-148

4. Functional Abnormalities of the Hypertrophied and Failing Heart

   1. Front Matter

      Pages 149-149

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   2. Subcellular Changes in Compensated and Failing Hypertrophied Hearts

      • Constantinos J. Limas

      Pages 151-170

   3. Autonomic Neural Control of the Failing Heart

      • M. J. Sole

      Pages 171-188

   4. The Inotropic Responsiveness of the Failing Heart

      • W. H. Newman, M. B. Frankis, J. G. Webb

      Pages 189-209

   5. New Inotropic Drugs for the Treatment of Heart Failure

      • Richard A. Goldstein

      Pages 210-223

   6. Transition to Cardiac Failure in Spontaneously Hypertensive Rats

      • J. M. Pfeffer, M. A. Pfeffer

      Pages 224-238

   7. Exercise and Pressure-Overload Induced Hypertrophy in Dog

      • H. Lowell Stone, Louis A. Sordahl

      Pages 239-252

   8. Do the Limits of Molecular Adaptations Induce Failure of the Hypertrophied Heart?

      • K. Schwartz, J. J. Mercadier, L. Rappaport, J. L. Samuel, D. Charlemagne, L. Lelievre et al.

      Pages 253-267

These Proceedings are from the Fifth Annual Meeting of the American Section of the International Society for Heart Research held at Hilton Head Island, South Carolina, September 21-24, 1983. The program and abstracts were published in the Journal of Molecular and Cellular Cardiology, Vol. 15, Supplement 4, September 1983, Academic Press. This Symposium Proceedings consists of three sections. Section I deals with the mechanical factors and their i'nfluence on coronary blood flow in the normal and failing heart. Section II is developed around the area of vascular smooth muscle and the factors that may control it which ultimately play such an important role in the regulation of coronary blood flow. Section III is primarily devoted to the mechanical aspects of the function of the heart in both hypertrophy and failure including the molecular changes in the myocyte, alterations in neural control, and in inotropic responsiveness of the hypertrophied and failing heart. The editors hope that these three areas encompass a significant body of new and ongoing information that will be helpful to those who work in these areas as well as those who treat patients with varying degrees of myocardial failure or with compromised coronary circulations. The editors express their appreciation to all the contributors and to Ms. Jeri B. McClain for assisting in the organization and compiling of this volume. Francis L. Abel, M. D. , Ph. D. Walter H. Newman, Ph. D.

• cardiology
• circulation
• drugs
• heart
• heart failure
• platelet

• Department of Physiology, University of South Carolina School of Medicine, Columbia, USA

  Francis L. Abel

• Medical University of South Carolina, Charleston, USA

  Walter H. Newman

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