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Cancer Immunology: Innovative Approaches to Therapy

  • Book
  • © 1986

Overview

Editors:
  1. Ronald B. Herberman

    1. Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, USA

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Part of the book series: Cancer Treatment and Research (CTAR, volume 27)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-X
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  2. Immunology of human T-cell leukemia/lymphoma (lymphotropic) viruses (the HTLV ‘family’)

    • Marjorie Robert-Guroff, Robert C. Gallo
    Pages 1-28

  3. Tumor specific antigens induced by mutagens and DNA hypomethylating agents: implications for the immunobiology of neoplasia

    • Robert S. Kerbel, Philip Frost, Douglas A. Carlow, Bruce E. Elliott
    Pages 29-67

  4. Destruction of Tumor Cells by Macrophages: Mechanisms of Recognition and Lysis and Their Regulation

    • Scott D. Somers, William J. Johnson, Dolph O. Adams
    Pages 69-122

  5. Mechanism of NK-cell mediated cytotoxicity

    • Pierre A. Henkart
    Pages 123-150

  6. Role of natural killer (NK) cells in the control of tumor growth and metastatic spread

    • E. Gorelik, R. Herberman
    Pages 151-176

  7. Monoclonal Antibody Therapy of Cancer: Preclinical Models and Investigations in Humans

    • A. Charles Morgan, Kenneth A. Foon
    Pages 177-200

  8. Abnormalities in Interleukin 2 Production and Response in Cancer and Possible Therapeutic Approaches

    • Roland Mertelsmann, Karl Welte
    Pages 201-220

  9. Back Matter

    Pages 221-229
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Keywords

About this book

This volume is the second in the 'Cancer Treatment and Research' series focussing on basic and clinical tumor immunology. It has a rather different focus or emphasis from that of the first volume, published two years ago. That work (Basic and Clinical Tumor Immunology, R.B. Herberman, ed., Martinus Nijhoff Publishers, 1983) devoted considerable attention to up­ dated summaries in various areas of classical tumor immunology: specific antitumor immunity, the immunologic competence of cancer patietns, char­ acterization of human tumor-associated antigens, the ability to propagate specifically immune T cells in culture in the presence of interleukin 2, and the use of such cells for adoptive immunotherapy of established tumors. of evidence concerning the immune However, it also reviewed the status surveillance hypothesis and pointed out the need to consider non-T cell mediated mechanisms of host resistance. In particular, one chapter sum­ marized information on the role of macrophages in host resistance against tumors. The present volume continues to emphasize one of the major themes of the first volume, innovative approaches to the therapy of cancer. It involves contributions from leading investigators on several primary types of therapeutic interventions related to monoclonal antibodies, the col­ laboration of monoclonal antibodies with macro phages to mediate antibody dependent cellular cytotoxicity, lymphokines, tumor vaccines, and natural killer cells. It also has an up-to-date summary of the immunologic aspects of the exciting and promising work being performed on human T cell leukemia virus in the laboratory of Dr. Robert Gallo.

Editors and Affiliations

  • Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, USA

    Ronald B. Herberman

Bibliographic Information

  • Book Title: Cancer Immunology: Innovative Approaches to Therapy

  • Editors: Ronald B. Herberman

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4613-2629-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Boston 1986

  • Hardcover ISBN: 978-0-89838-757-5Published: 28 February 1986

  • Softcover ISBN: 978-1-4612-9643-0Published: 04 January 2012

  • eBook ISBN: 978-1-4613-2629-8Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: X, 230

  • Topics: Oncology

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