Overview
- Editors:
-
-
Joel F. Habener
-
Laboratory of Molecular Endocrinology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, USA
Access this book
Other ways to access
Table of contents (18 chapters)
-
Front Matter
Pages i-xvii
-
-
-
-
- Gerhard Heinrich, Joel F. Habener
Pages 69-92
-
- Richard H. Goodman, Marc R. Montminy, Malcolm J. Low, Joel F. Habener
Pages 93-119
-
- David D. Moore, Richard F Selden, Edouard Prost, Daniel S. Ory, Howard M. Goodman
Pages 121-135
-
-
-
- Michael Uhler, Edward Herbert
Pages 207-228
-
-
- Michael G. Rosenfeld, Stuart Leff, Susan G. Amara, Ronald M. Evans
Pages 277-301
-
-
- François Rougeon, Jean-Jacques Panthier, Inge Holm, Florent Soubrier, Pierre Corvol
Pages 321-342
-
-
-
- K. Richter, W. Hoffmann, R. Egger, G. Kreil
Pages 391-404
-
- R. Vlasak, I. Malec, G. Kreil
Pages 405-412
-
-
Back Matter
Pages 435-441
About this book
The peptide hormones are small proteins that regulate cellular metabolism through their specific interactions with tissues of the endocrine, nervous, and immune systems, as well as in embry onic development. During the past ten years, refinements in the techniques of recombinant DNA technology have resulted in the cloning of genes encoding approximately 50 different hormonal and regulatory peptides, including those in which the peptides themselves and the mRNAs encoding the peptides are present in only trace amounts in the tissues of origin. In addition to provid ing the coding sequences of recognized hormonal and regulatory peptides, gene sequencing has uncovered new bioactive peptides encoded in the precursor pro hormones that are then liberated along with the hormonal peptides during cellular cleavages of the precursors. The encoding of multiple peptides in a single mono cistronic mRNA appears to be a genetic mechanism for the gener ation of biologic diversification without requiring amplification of gene sequences. Two of the objectives in the assembly of this book are to pre sent, in one volume, the known primary structures of the genes encoding several of the polypeptide hormones and related regulatory peptides, and to provide an account of the various ap proaches that have been used to identify and select the cloned genes encoding these polypeptides. The contents of the two in troductory chapters are intended to provide the reader with a brief background of the approaches to gene cloning and the struc ture and expression of hormone-encoding genes.
Editors and Affiliations
-
Laboratory of Molecular Endocrinology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, USA
Joel F. Habener
