Acromegaly

1. Front Matter

   Pages i-xi

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2. The Life of Doctor Pierre Marie: A Great-Granddaughter’s View

   1. The Life of Doctor Pierre Marie: A Great-Granddaughter’s View

      • Martin Pierre Marie Granier

      Pages 1-3

3. Molecular Biology and Physiology of GH Action

   1. Front Matter

      Pages 5-5

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   2. Etiology of Acromegaly from the Neuroendocrine Point of View: A Historical Perspective

      • Seymour Reichlin

      Pages 7-15

   3. Human Growth Hormone Gene Regulation in Somatotroph Cell Cultures

      • Shlomo Melmed, Shunichi Yamashita, Sara Pixley

      Pages 17-25

   4. Detection of the Multiple Forms of Human Growth Hormone

      • U. J. Lewis, R. N. P. Singh, L. J. Lewis, N. Abadi

      Pages 27-34

   5. Molecular Heterogeneity of Circulating Growth Hormone in Acromegaly

      • Gerhard Baumann

      Pages 35-43

   6. Somatomedin Gene Expression

      • Andrew R. Hoffman, Susan N. Perkins, Ines Zangger, James Eberwine, Jack D. Barchas, Phillip James et al.

      Pages 45-53

   7. Somatomedin Action and Tissue Growth Factor Receptors

      • Ron G. Rosenfeld, Gian Paolo Ceda, Darrell M. Wilson, Andrew R. Hoffman

      Pages 55-63

   8. The Mechanism of the Growth-Promoting Action of Growth Hormone

      • E. Martin Spencer, Nicole Schlechter, Sharon Russell, Charles Nicoll

      Pages 65-72

4. Regulation of Growth Hormone Secretion

   1. Front Matter

      Pages 73-73

      PDF

   2. Somatostatin and the Syndrome of Acromegaly

      • Richard J. Robbins

      Pages 75-82

   3. Growth Hormone Secretion in Acromegaly

      • Hiroo Imura, Yuzuru Kato, Eiji Ishikawa

      Pages 83-95

   4. Actions of GRF in Man

      • Michael O. Thorner, Mary Lee Vance, William S. Evans, Alan D. Rogol, Jean S. Chitwood, Robert M. Blizzard et al.

      Pages 97-104

   5. GRF Secretion in Man

      • M. D. Page, C. Dieguez, I. Weeks, S. Woodhead, M. F. Scanlon

      Pages 105-113

   6. Ectopic GRH Syndromes

      • Lawrence A. Frohman, Thomas R. Downs

      Pages 115-125

5. Diagnosis of Acromegaly

   1. Front Matter

      Pages 127-127

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   2. Clinical Developments Over the Past 100 Years of Acromegaly

      • William H. Daughaday

      Pages 129-137

   3. Gonadal Steroid Modulation of Growth Hormone Secretory Patterns in the Rat

      • William J. Millard, Thomas O. Fox, Thomas M. Badger, Joseph B. Martin

      Pages 139-150

   4. Pathogenesis of Acromegaly

      • Mark E. Molitch

      Pages 151-163

The manuscripts in this volume were contributed by the speakers invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The meeting was organized to commemorate the description of acromegaly by the French physician Pierre Marie, in 1886. The members of the Scientific Committee spent many hours assisting us in ensuring an outstanding meeting. The support of Serono Symposia, USA in all phases of the planning and execution of the meeting was sincerely appreciated and was highly professional. Special recognition roust be extended to Professor Roger Guillemin of the Salk Institute, whosp interest in medical history led him to devote a great deal of time and personal expense in obtaining information about the life of Pierre Marie. Dr. GuilIemin's presentation on the life and times of Marie was an extraordinary overview of the cultural, social, and scientific backgrounds in which Marie came to describe the disease, acromegaly. Dr. Guillemin' s findings, which were presented at the main banquet in a splendid audiovisual presentation, were clearly the highlight of the meeting and will long be remembered by the attendees. We were also honored by the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her address at the banquet, Dr. Granier provided several delightful and intimate vignettes concerning Pierre Marie, using old family records and photographs. The Scientific Committee wishes to extend its gratitude to Dr. Granier for adding immeasurably to the historical atmosphere of the meeting.

• growth
• growth factor
• growth hormone
• hormone
• metabolism
• steroid
• diabetes

• Yale University, New Haven, USA

  Richard J. Robbins

• Cedars Sinai Medical Center, UCLA School of Medical Science, Los Angeles, USA

  Shlomo Melmed

Policies and ethics