A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer

1. Front Matter

   Pages i-xii

   PDF

2. Prostate Cancer: The Magnitude of the Problem in the United States

   1. Prostate Cancer: The Magnitude of the Problem in the United States

      • H. Ballentine Carter, Donald S. Coffey

      Pages 1-7

3. Incidence, Survival and Mortality Trends in Prostate Cancer

   1. Incidence, Survival and Mortality Trends in Prostate Cancer

      • Edward Sondik

      Pages 9-16

4. Localized Disease

   1. Incidental Cancer

      1. Diagnosis of Stage a Prostate Cancer in the People’s Republic of China

         • Gary J. Miller

         Pages 17-24

      2. Prevention of Prostatic Carcinogenesis — Is it Realistic?

         • John T. Isaacs

         Pages 25-34

   2. Tumor Volume and Natural History of Stage A1 and A2 Disease

      1. The Proto-Biology of Prostate Cancer

         • William A. Gardner Jr., Donald E. Culberson

         Pages 35-39

      2. The Classification and Prognosis of Untreated Stage A1 and A2 Prostate Cancer with a Comparison of their Histologic Findings at Radical Prostatectomy

         • Jonathan I. Epstein, Patrick C. Walsh

         Pages 41-55

      3. Role of Histology in Selecting Treatment for Stage A1 and Stage A2 Disease

         • David F. Paulson

         Pages 57-64

      4. Panel Discussion: Management of Stages A1 and A2 Disease

         • Willet F. Whitmore Jr.

         Pages 65-84

   3. Management of Clinically Manifest Stages B1 and B2 Disease

      1. External Beam Irradiation of Prostatic Cancer

         • Malcolm A. Bagshaw

         Pages 85-108

      2. Long-Term Results After Combined Radioactive Gold Seed Implantation and External Beam Radiotherapy for Localized Prostatic Cancer

         • C. Eugene Carlton Jr., Peter T. Scardino

         Pages 109-121

      3. Radical Prostatectomy for the Treatment of Localized Prostatic Cancer

         • Patrick C. Walsh, Joseph E. Oesterling, Herbert Lepor

         Pages 123-140

      4. Panel Discussion: Management of Stages B1 and B2 Disease

         • Donald S. Coffey

         Pages 141-147

5. Invasive Disease

   1. Stages C, D0, and D1 Disease

      1. Adjuvant Radiotherapy Following Radical Prostatectomy: Results and Complications

         • Robert P. Gibbons, B. Sharon Cole, R. Garratt Richardson, Roy J. Correa Jr., George E. Brannen, J. Tate Mason et al.

         Pages 149-158

      2. Treatment of Patients with Positive Margins

         • Robert P. Gibbons

         Pages 159-160

      3. The Long-Term Success of Local Radiation Therapy in Preventing Tumor Regrowth in the Treated Field

         • William U. Shipley, Noreen M. Coachman, George R. Prout Jr., Alex F. Althausen, Stephen P. Dretler, Niall M. Heney et al.

         Pages 161-168

      4. Is Salvage Prostatectomy a Benefit?

         • J. Edson Pontes

         Pages 169-172

      5. Accuracy of Grading and Staging Prostate Cancer

         • William J. Catalona

         Pages 173-181

      6. Radical Prostatectomy and the Influence of Early Endocrine Therapy for Stage D1 Prostate Cancer: Long-Term Follow-Up Study

         • Robert P. Myers, Terry M. Therneau, Horst Zincke, David C. Utz

         Pages 183-194

      7. Panel Discussion: Management of Stages C, D0 and D1 Disease

         • Martin I. Resnick

         Pages 195-204

These proceedings emanate from the Second Prouts Neck Conference on prostate cancer held on October 17-19, 1986, the theme of which was treat­ ment, with focus on current issues and future research that is needed to answer critical questions related to optimal management of the various stages of prostate cancer. The objective was to reveal the most crucial problems impeding progress and to crystallize the combined multidisci­ plinary input generated by the conference into focused concepts or recommendations for presentation to the National Cancer Institute (NCI) , with the ultimate intent of targeting research to address the priority issues identified. In organizing the workshop, every effort was made to maintain a multidisciplinary balance among nationally renowned authorities on prostate cancer. Thus, leading surgeons, radiation and medical onco­ logists and biostatisticians were in equal presence. While there were spirited exchanges with careful scrutiny and critique of all data pre­ sented, there was a common belief that the challenge of prostate cancer would be best approached in this multidisciplinary Organ Systems-oriented fashion. During the course of the conference, it became apparent to all present that major nomenclature and procedural barriers have made it generally difficult, and frequently impossible, to compare results of clinical research.

• Grading
• Staging
• classification
• diagnosis
• therapy

• Johns Hopkins University and Hospital, Baltimore, USA

  Donald S. Coffey

• University Hospitals of Cleveland, Cleveland, USA

  Martin I. Resnick

• National Cancer Institute, Bethesda, USA

  F. Andrew Dorr

• Roswell Park Memorial Institute, Buffalo, USA

  James P. Karr

Policies and ethics