Alterations in the Neuronal Cytoskeleton in Alzheimer Disease

1. Front Matter

   Pages i-x

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2. Neurofilaments: A Review and Update

   • Steven S. M. Chin, Ronald K. H. Liem

   Pages 1-24

3. The Phosphorylation of the Microtubule-Associated Tau Proteins

   • Jacques Baudier, R. David Cole

   Pages 25-32

4. Human Amyloidosis and In Vitro Formation of Alzheimer Amyloid Fibrils

   • Eduardo M. Castaño, Blas Frangione

   Pages 33-44

5. Cloning of Neurofibrillary Tangle-Related Genes

   • Kenneth S. Kosik, Rachael Neve

   Pages 45-52

6. Ubiquitin in Alzheimer and other Neurodegenerative Diseases

   • George Perry, Valeria Manetto, Paul Mulvihill

   Pages 53-59

7. Neuronal Fibrillar Cytoskeleton and Endomembrane System Organization in Alzheimer’s Disease

   • Mark Ellisman, Rama Ranganathan, Thomas Deerinck, Stephen Young, Robert Terry, Suzanne Mirra

   Pages 61-73

8. Transformation of the Neurofilamentous Network Components into PHF-Like Strands and PHF Paracrystals

   • J. Metuzals, Y. Robitaille, S. Houghton, S. Gauthier, R. Leblanc

   Pages 75-95

9. Intraneuronal and Extracellular Filaments in the Pathogenesis of Alzheimer’s Disease

   • Dennis J. Selkoe

   Pages 97-107

10. Alterations of the Neuronal Cytoskeleton in Alzheimer’s Disease and Related Conditions

    • Khalid Iqbal, Inge Grundke-Iqbal, Henryk M. Wisniewski

    Pages 109-136

11. Alteration of the Neurofilament-Microtubule Network in Alzheimer Disease and Other Neurodegenerative Disorders

    • George Perry, Valeria Manetto, Michelle Onorato, Madelyn Weiss, Paul Mulvihill, Pamela Galloway et al.

    Pages 137-149

12. Immunochemical Studies of the Relationship Between the Neuronal Cytoskeleton and Neurofibrillary Tangles

    • D. P. Hue, J. P. Brion, P. A. Robinson, B. H. Anderton

    Pages 151-163

13. Monoclonal Antibodies Show Cross-Reactivity of Alzheimer Neurofibrillary Tangles and Heat-Stable Microtubule-Associated Proteins

    • Dennis W. Dickson, Hanna Ksiezak-Reding, Alex Crowe, Shu-Hui Yen

    Pages 165-180

14. An Immunocytochemical Comparative Analysis of Tau in Neurodegenerative Diseases

    • Nancy J. Pollock, Suzanne S. Mirra, John G. Wood

    Pages 181-189

15. Cytoskeletal Abnormalities in Parkinson’s Disease

    • James E. Goldman

    Pages 191-197

16. Microfilament Involvement in Hirano Body Formation

    • Pamela G. Galloway, George Perry

    Pages 199-210

17. Back Matter

    Pages 211-229

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The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these questions are addressed in a historical perspect­ ive in light of new data that allows the reinterpretation of previously reported results. Contributions are based on many of the major tech­ niques of modern biology including biochemistry, molecular biology, electron microscopy and immunocytochemistry. In the view of the editor, this volume is being written at a time when our understanding of the cytopathology of Alzheimer disease is moving from predominantly descriptive to both analytical and mechanistic. I hope that this contribution will provide impetus to speed this transi­ tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation for the computer­ generated color figure on page 65 is gratefully acknowledged.

• Alzheimer
• Parkinson
• biochemistry
• biology
• neurons

• Case Western Reserve University, Cleveland, USA

  George Perry

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