Peritoneal Carcinomatosis: Principles of Management

1. Front Matter

   Pages i-xix

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2. General Principles

   1. Metastatic inefficiency: Intravascular and intraperitoneal implantation of cancer cells

      • Leonard Weiss

      Pages 1-11

   2. Intraperitoneal immunotherapy of cancer: A review of options for treatment

      • Hedda H. van Ravenswaay Claasen, Alexander M. M. Eggermont

      Pages 13-40

   3. Pharmacokinetics of the peritoneal-plasma barrier after systemic mitomycin C administration

      • Paul H. Sugarbaker, O. Anthony Stuart, Joan Vidal-Jove, Ann Marie Pessagno, Ernst A. DeBruijn

      Pages 41-52

   4. Peritoneal-plasma barrier

      • Pierre Jacquet, Paul H. Sugarbaker

      Pages 53-63

   5. Patterns of spread of recurrent intraabdominal sarcoma

      • Tessa A. Sugarbaker, David Chang, Patricia Koslowe, Paul H. Sugarbaker

      Pages 65-77

   6. Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology

      • Paul H. Sugarbaker

      Pages 79-100

   7. In vitro pharmalogic rationale for intraperitoneal regional chemotherapy

      • Karl H. Link, U. Butzer, J. Pillasch, G. Hepp, H. G. Beger

      Pages 101-114

   8. Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes

      • Ralph S. Freedman, Chris D. Platsoucas

      Pages 115-146

   9. Role of omentum-associated lymphoid tissue in the progression of peritoneal carcinomatosis

      • Masataka Shimotsuma, Morio Shirasu, Akeo Hagiwara, Toshio Takahashi

      Pages 147-154

   10. Cancer cell seeding during abdominal surgery: Experimental studies

       • Frans A. N. Zoetmulder

       Pages 155-161

   11. Krukenberg syndrome as a natural manifestation of tumor cell entrapment

       • Paul H. Sugarbaker, Andrew M. Averbach

       Pages 163-191

3. Techniques

   1. Peritoneal carcinomatosis and radioimmunoguided surgery

      • Schlomo Schneebaum, Mark W. Arnold, Alfred E. Staubus, Edward W. Martin Jr.

      Pages 193-209

   2. Diffuse and gross peritoneal carcinomatosis treated by intraperitoneal hyperthermic chemoperfusion

      • Friedrich Kober, Agnes Heiss, Rudolf Roka

      Pages 211-219

   3. Complications of heated intraperitioneal chemotherapy and strategies for prevention

      • Brian W. Loggie, Ronald A. Fleming

      Pages 221-233

   4. Peritonectomy procedures

      • Paul H. Sugarbaker

      Pages 235-253

   5. Progressive release of the left colon for a tension-free colorectal or coloanal anastomosis

      • Paul H. Sugarbaker

      Pages 255-261

   6. Radiology of peritoneal carcinomatosis

      • Ann G. Archer, Paul H. Sugarbaker, James S. Jelinek

      Pages 263-288

   7. Methodologic considerations in treatment using intraperitoneal chemotherapy

      • Andrew M. Averbach, Paul H. Sugarbaker

      Pages 289-309

   8. Safety constiderations in the use of intraoperative intraperitoneal chemotherapy

      • Susan K. White, Arvil D. Stephens, Barbara Dowjat, Paul H. Sugarbaker

      Pages 311-316

Paul Sugarbaker and his colleagues have persevered in the study and treat­ ment of peritoneal carcinomatosis. The peritoneal cavity has many unique and incompletely appreciated properties. These properties, coupled with the biologic behavior of many cancers, results in the seeding and growth of these cancers on the peritoneum. Many of these cancers remain localized to the peritoneum only, never metastasizing to other sites. One possible reason for this may be the obstruction of the afferent lymphatics on the undersurface of the diaphragm. The mucopolysaccharides produced by many of these neoplasma are probably viscous enough to obstruct these lymphatics, leading to the syndrome of pseudomyxoma peritonei. Many of the neoplasms taking residence on the peritoneum have extremely long cell-cycle times and are resistant to radiotherapy and many chemotherapeutic agents. How­ ever, much can be done for these patients - resection of primary cancers, omentectomies to reduce ascites formation, management of recurrent ascites, management of intestinal obstruction, nutritional care, and, hopefully, intraperitoneal chemotherapy. We have reviewed many of these problems in the past [1-7]. Dr. Sugarbaker and his colleagues have organized the current state of knowledge and technology for continuing use. The book provides a basis for thoughtful, prospective research planning. John S. Spratt, M. D. , F. A. C. S. Professor of Surgery The James Graham Brown Cancer Center University of Louisville Louisville, Kentucky References 1. Long RTL, Spratt JS, Dowling E.

• Staging
• carcinoma
• cell
• immunotherapy
• lymphocytes
• metastasis
• ovarian cancer
• radiology
• surgery
• tumor

• Washington Cancer Institute, USA

  Paul H. Sugarbaker

Policies and ethics