Iodine and the Brain

1. Front Matter

   Pages i-ix

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2. Introduction

   1. Iodine and the Brain

      • Basil S. Hetzel

      Pages 1-3

3. Molecular Biology of Iodine and Thyroid Hormones in the Brain

   1. Regulation of Thyroid Hormone Metabolism in the Brain

      • P. Reed Larsen

      Pages 5-18

   2. Thyroid Hormone Receptor Related mRNAs

      • Vera M. Nikodem, Tomoaki Mitsuhashi

      Pages 19-27

   3. A Neural Thyroid Hormone Receptor Gene

      • Cary Weinberger, David J. Bradley, Linda S. Brady, Catherine C. Thompson, Ronald M. Evans

      Pages 29-37

   4. Thyroid Hormone Transport from Blood into Brain Cells

      • Jacob Robbins, Edison Goncalves, Mark Lakshmanan, Daniels Foti

      Pages 39-50

4. Thyroid Hormone Control of Brain Development

   1. Thyroid Hormone Receptors in the Developing Brain

      • Philippe De Nayer, Béatrice Dozin

      Pages 51-58

   2. Thyroid Hormone Regulation of Specific mRNAS in the Developing Brain

      • S. A. Stein, D. R. Shanklin, P. M. Adams, G. M. Mihailoff, M. B. Palnitkar, B. Anderson

      Pages 59-78

   3. Thyroid Influences on the Developing Cerebellum and Hippocampus of the Rat

      • Jean M. Lauder

      Pages 79-90

   4. Quantitative Studies of the Effects of Hypothyroidism on the Development of the Cerebral Cortex

      • Antonio Ruiz-Marcos

      Pages 91-102

   5. Microtubule Assembly: Regulation by Thyroid Hormones

      • J. Nunez, D. Couchie, J. P. Brion

      Pages 103-112

   6. Investigation of Myelinogenesis in Vitro: Transient Expression of 3,5,3’-Triiodothyronine Nuclear Receptors in Secondary Cultures of Pure Rat Oligodendrocytes

      • L. L. Sarliève, F. Besnard, G. Labourdette, B. Yusta, A. Pascual, A. Aranda et al.

      Pages 113-130

   7. Developmental and Thyroid Hormone Regulation of Na,K-ATPase Isoforms in the Brain

      • Alicia McDonough, Cheryl Schmitt

      Pages 131-138

   8. Thyroid Hormones and Neurotransmitter Systems: An Interaction with Nerve Growth Factor in the Regulation of Cholinergic Neurones

      • Ambrish J. Patel, Anthony Hunt, Jozsef Kiss

      Pages 139-149

   9. Ontogeny of Thyroid Hormone-Processing Systems in Rat Brain

      • Mary B. Dratman, Floy L. Crutchfield, Janice T. Gordon

      Pages 151-166

5. The Fetus and Iodine Deficiency

   1. Development of Fetal Thyroid System Control

      • Delbert A. Fisher

      Pages 167-176

   2. The Fetus and Iodine Deficiency: Marmoset and Sheep Models of Iodine Deficiency

      • Basil S. Hetzel, Mark L. Mano, J. Chevadev

      Pages 177-186

   3. Models of Fetal Iodine Deficiency

      • Gabriel la Morreale de Escobar, Carmen Ruiz de Oña, María Jesús Obregón, Francisco Escobar del Rey

      Pages 187-201

   4. Screening for Congenital Hypothyroidism; Beneficial Effects on Neuropsychological Development

      • J. H. Dussault, J. Glorieux

      Pages 203-207

   5. Placental Deiodination of the Thyroid Hormones

      • Lewis E. Braverman

      Pages 209-218

This volume contains the proceedings of a conference held at the National Institutes of Health in Bethesda on March 21-23. 1988. jointly sponsored by the International Council for Control of Iodine Deficiency Disorders (ICCIDD) and the Fogarty International Center of the National Institutes of Health. Several themes converged to make this meeting timely. The first is an increasing awareness of iodine deficiency disorders as a world-wide problem of public health and a preventable cause of mental deficiency. and as a subject of scientific effort. Increased interest in these problems owes a great deal to accessibility to remote and under­ developed areas of the world where iodine deficiency persists. As with any subject. greater scrutiny yields unexpected complexity and interest. It is true that provision of iodine. typically as iodized salt, is the necessary and sufficient preventative for iodine deficiency disorders. without including endemic cretinism. This provision is a governmental, economic and social problem. Apart from this, however, the scientific and medical problem of iodine deficiency and its effect on brain development and function is one of great interest and importance for developmental neurology and psychology. Even though the specific preventative agent is known, we do not totally understand the neurobiological questions raised.

• biology
• brain
• cortex
• metabolism
• migration
• receptor
• regulation

• Duke University Medical Center, Durham, USA

  G. Robert DeLong

• National Institutes of Health, Bethesda, USA

  Jacob Robbins, Peter G. Condliffe

Policies and ethics