Biomedical Advances in Aging

1. Front Matter

   Pages i-xi

   PDF

2. Molecular Biology, Virology, and Genetics of Alzheimer’s Disease

   1. Front Matter

      Pages 1-1

      PDF

   2. Brain Amyloidoses

      • D. Carleton Gajdusek, C. Joseph Gibbs Jr.

      Pages 3-24

   3. Prions Causing Neurodegenerative Diseases

      • Ruth Gabizon, Michael P. McKinley, Darlene Groth, Stanley B. Prusiner

      Pages 25-37

   4. The Molecular Genetics of Alzheimer’s Disease

      • J. A. Hardy, M. J. Owen, A. M. Goate, L. A. James, A. R. Haynes, R. Williamson et al.

      Pages 39-42

   5. A Developmental Genetic Approach to the Analysis of Aging Processes

      • Thomas E. Johnson

      Pages 43-49

   6. Alzheimer’s Disease

      • George G. Glenner

      Pages 51-62

   7. Evidence for the Molecular Basis of Aging and Sequestration of Mammalian Erythrocytes

      • David Aminoff

      Pages 63-73

   8. α1á-Antichymotrypsin

      • Huntington Potter, Carmela R. Abraham

      Pages 75-88

   9. Replication of Adenovirus 2 and Adeno-Associated Virus 2 in Young and Senescent Human Diploid Fibroblasts

      • Piruz Nahreini, Arun Srivastava

      Pages 89-107

   10. Lactoferrin Immunoreactivity and Binding Sites in Neurons, Neuritic Plaques, and Neurofibrillary Tangles in Alzheimer’s Disease

       • Alexander P. Osmand, Robert C. Switzer III

       Pages 109-124

   11. Immunological Investigation of Thymic-Dependent Immunity in Normal Aging and in Patients with Senile Dementia of Alzheimer Type

       • Giancarlo Savorani, Gabriele Sarti, Afro Salsi, Francesco Cavazzuti, Lucio Zanichelli, Giuseppe Tucci et al.

       Pages 125-133

3. Metabolic, Membrane, and Cellular Markers and Models

   1. Front Matter

      Pages 135-135

      PDF

   2. Chronic Diseases and Disorders

      • Jacob A. Brody

      Pages 137-142

   3. Changes in Receptors and Signal Transduction Events during Aging

      • George S. Roth

      Pages 143-146

   4. Molecular Aging of Membrane Molecules and Cellular Removal

      • Marguerite M. B. Kay

      Pages 147-161

   5. Health Watch: A Longitudinal Prospective Study of Healthy Aging in 2200 Individuals

      • Robert M. Schmidt, Meiwen Wu, George Z. Williams

      Pages 163-172

   6. Plasma α-Tocopherol Levels in Men and Women of Different Ages

      • Carlo Vergani, Patrizia Stefanoni, Monica Grazioli, Marigrazia Clerici

      Pages 173-179

   7. Polyenoic Fatty Acid Metabolism and Prostaglandin Biosynthesis in Aged Persons

      • Olaf Adam

      Pages 181-185

   8. Altered Phosphatidylinositol Breakdown in Polymorphonuclear Leukocytes with Aging

      • Tamàs Fülöp Jr., Zsuzsa Varga, Jozsef Csongor, Andràs Leovey, Gabriella Foris, Marie-Paule Jacob et al.

      Pages 187-194

The VIIIth Annual International Spring Symposium on Health Sciences held at the George Washington University School of Medicine in Washington, D.C., attracted over three hun­ dred fifty scientists from twenty-five countries. The leading scientific experts in the field reported on recent biomedical advances in aging. They provided an up-to-date account of the molecular, genetic, nutritional, and immunological mechanisms associated with the aging process and approaches to intervention and treatment of the major disorders associated with the aging process, including Alzheimer's disease. A unique aspect of this meeting was a concurrent one-day hearing of the U.S. Senate Sub-Committee on Aging, organized by the Alliance for Aging Research. The theme for the hearing was "Advances in Aging Research." Seven scientists attending our aging sym­ posium were asked to testify. They were Drs. Carl Cotman (University of California-Irvine), Trudy Bush (Johns Hopkins University), Takashi Makinodan (University of California-Los Angeles), William Ershler (University of Wisconsin-Madison), Gino Doria (ENEA, Rome), Mr. Dan Perry (Director of the Alliance for Aging Research), and myself.

• Alzheimer
• aging
• dementia
• senescence
• therapy

From Book News, Inc.
The VIIIth Annual Symposium provides new information on molecular and immunological mechanisms, intervention and clinical approaches to treatment of diseases associated with aging, and with the aging process itself. The 56 papers are arranged into six major sections covering: molecular biology, virology, and genetics of Alzheimer's disease; metabolic, membrane, and cellular markers and models; role of nutritional, dietary, and immune factors in the pathogenesis of aging; immunological components and immunoregulation in aging; the brain, neuroendocrine circuits, pathology, and plasticity; and immunological, endocrine, and pharmacological approaches to treatment of diseases of aging.
Annotation copyright Book News, Inc. Portland, Or

• The George Washington University Medical Center, USA

  Allan L. Goldstein

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