Blood Substitutes

1. Front Matter

   Pages i-x

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2. Transfusion Alternatives: Impact on Blood Banking Worldwide

   • Peter Tomasulo

   Pages 1-19

3. Demonstration of the Efficacy of a Therapeutic Agent

   • Joseph C. Fratantoni

   Pages 20-24

4. A Physiologic Basis for the Transfusion Trigger

   • Robert M. Winslow

   Pages 25-41

5. Combat Casualties, Blood, and Red Blood Cell Substitutes: A Military Perspective in 1995

   • Jon C. Bowersox, John R. Hess

   Pages 42-52

6. Clinical Development of Perfluorocarbon-based Emulsions as Red Cell Substitutes

   • Robert J. Kaufman

   Pages 53-75

7. Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes

   • James M. Manning

   Pages 76-89

8. Encapsulation of Hemoglobin in Liposomes

   • Alan S. Rudolph

   Pages 90-104

9. Stability and Toxicity of Hemoglobin Solutions

   • Kim D. Vandegriff

   Pages 105-131

10. Red Cell Substitutes in the Kidney

    • Roland C. Blantz, Andrew P. Evan, Francis B. Gabbai

    Pages 132-142

11. A Theoretical Analysis of Oxygen Transport: A New Strategy for the Design of Hemoglobin-Based Red Cell Substitutes

    • Kim D. Vandegriff, Robert M. Winslow

    Pages 143-154

12. Microcirculatory Consequences of Blood Substitution with αα-Hemoglobin

    • Amy G. Tsai, Heinz Kerger, Marcos Intaglietta

    Pages 155-174

13. Oxygen Delivery Regulation: Implications for Blood Substitutes

    • Paul C. Johnson, Keith Richmond, Ross D. Shonat, Andreas Toth, Mihlos Pal, Marc E. Tischler et al.

    Pages 175-186

14. Tumor Oxygenation and Radiosensitivity

    • Herman Suit

    Pages 187-199

This volume contains a collection of essays by selected authors who are active in the field of blood substitutes research or closely allied disciplines. These essays were delivered as lectures by the authors at the second annual "Current Issues in Blood Substitute Research and Development - 1995" course sponsored jointly by the Departments of Medicine and Bioengineer­ ing, University of California, San Diego, the National Institutes of Health (NHLBI), and the U.S. Army on March 30, 31, and April 1, 1995 in San Diego. This course had three goals: to present fundaniental discussions of scientific issues critical to further development of artificial oxygen carriers, to provide academicians a forum to discuss their current research, and to provide the companies involved in developing products the opportunity to update the audience on their progress. The organization owes much to the solicited comments of the attendees of the 1994 course. We would like especially to thank the U.S. Army, particularly through the efforts of COL John Hess, who provided significant funding to make publication of this volume possible. In addition, a number of the participating companies provided additional financial support to offset the costs of the course. These include Alliance Pharmaceutical Corp., Hemosol, Nippon Oil and Fat, Northfield Laboratories, and Ortho Biotech.

• Biologie
• Medizin
• biology
• blood
• blood cell
• cell
• development
• health
• joint
• medicine
• organizations
• research

• School of Medicine, University of California, San Diego, USA

  R. M. Winslow, K. D. Vandegriff

• Department of Applied Mechanics and Engineering Sciences, University of California, San Diego, USA

  M. Intaglietta

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