Genetic Mapping and DNA Sequencing

1. Front Matter

   Pages i-xi

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2. An Introduction to Recombination and Linkage Analysis

   • Mary Sara McPeek

   Pages 1-14

3. Monte Carlo Methods in Genetic Analysis

   • Shili Lin

   Pages 15-38

4. Interference, Heterogeneity and Disease Gene Mapping

   • Bronya Keats

   Pages 39-48

5. Estimating Crossover Frequencies and Testing for Numerical Interference with Highly Polymorphic Markers

   • Jurg Ott

   Pages 49-63

6. What is a genetic map function?

   • T. P. Speed

   Pages 65-88

7. Haplotyping Algorithms

   • Eric Sobel, Kenneth Lange, Jeffrey R. O’Connell, Daniel E. Weeks

   Pages 89-110

8. Statistical Aspect of Trait Mapping Using a Dense Set of Markers: A Partial Review

   • Josée Dupuis

   Pages 111-131

9. A Comparative Survey of Non-Adaptive Pooling Designs

   • D. J. Balding, W. J. Bruno, D.C Torney, E. Knill

   Pages 133-154

10. Parsing of Genomic Graffiti

    • Clark Tibbetts, James Golden III, Deborah Torgersen

    Pages 155-181

11. Improving DNA Sequencing Accuracy and Throughput

    • David O. Nelson

    Pages 183-206

12. Assembly of Shotgun Sequencing Data

    • Xiaoqiu Huang

    Pages 207-215

13. Back Matter

    Pages 216-221

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Genetics mapping, physical mapping and DNA sequencing are the three key components of the human and other genome projects. Statistics, mathematics and computing play important roles in all three, as well as in the uses to which the mapping and sequencing data are put. This volume edited by key researchers Mike Waterman and Terry Speed reviews recent progress in the area, with an emphasis on the theory and application of genetic mapping.

• DNA
• DNA sequencing
• Haplotype
• genetics
• recombination
• statistics

• Department of Statistics, University of California at Berkeley, Berkeley, USA

  Terry Speed

• Department of Mathematics and Molecular Biology, University of Southern California, Los Angeles, USA

  Michael S. Waterman

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