Frontiers in Hypertension Research

1. Front Matter

   Pages i-xxxix

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2. Frontiers in Hypertension Research: Past, Present and Future Introduction

   1. Frontiers in Hypertension Research: Past, Present and Future Introduction

      • John H. Laragh

      Pages 1-5

3. The Variation in Risk Among Hypertensive Patients: Is Broad Scale Therapy to Help Only a Few Justifiable? What Pressure Levels Should Be Treated?

   1. Front Matter

      Pages 7-7

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   2. Position Paper: The Variation in Risk Among Hypertensive Patients: Is Broad Scale Therapy to Help Only a Few Justifiable? What Pressure Levels Should Be Treated

      • M. H. Alderman

      Pages 9-14

   3. Interpretation of the Hypertension Detection and Follow-up Program

      • Richard D. Remington

      Pages 15-16

   4. Implications of Framingham Study Data for Treatment of Hypertension: Impact of Other Risk Factors

      • William B. Kannel

      Pages 17-21

   5. Factors Affecting Morbidity and Mortality and the Risk Factor Concept

      • Reuel A. Stallones

      Pages 22-23

   6. Australian Therapeutic Trial in Mild Hypertension

      • A. E. Doyle

      Pages 24-28

   7. Treatment of Borderline and Mild Hypertension: The Oslo Study

      • A. Helgeland, I. Hjermann, I. Holme, P. G. Lund-Larsen, P. Leren

      Pages 29-34

4. Dietary Sodium and Human Hypertension

   1. Front Matter

      Pages 35-35

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   2. Position Paper: Dietary Sodium and Human Hypertension

      • George Pickering

      Pages 37-42

   3. Sodium Deprivation as an Approach to Hypertension

      • Edward D. Freis

      Pages 43-45

   4. Sodium and Other Dietary Factors in Experimental and Human Hypertension: The Japanese Experience

      • Yukio Yamori, Yasuo Nara, Masahiro Kihara, Ryoichi Horie, Akira Ooshima

      Pages 46-48

   5. Metabolic Risks of Diuretic Therapy

      • Richard P. Ames, Peter Hill

      Pages 49-53

   6. Sodium and Blood Pressure: A New Zealand Study

      • F. O. Simpson, Judith Paulin

      Pages 54-57

   7. Blood Pressure in Sodium Fed Humans

      • Myron H. Weinberger, Friedrich C. Luft, Richard Bloch, David P. Henry, Arthur E. Weyman, Laura I. Rankin

      Pages 58-61

   8. Adverse Effects of Diuretic Therapy

      • T. Morgan, J. Myers, W. Adam

      Pages 62-68

5. Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension

   1. Front Matter

      Pages 69-69

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   2. Position Paper: Sodium Metabolism: The Sodium-Potassium Membrane Pump and Volume Overload Hypertension

      • Francis J. Haddy, Motilal B. Pamnani, David L. Clough

      Pages 71-80

   3. Erythrocyte Sodium Extrusion in Primary Hypertension

      • Ricardo P. Garay, Philippe Meyer

      Pages 81-83

reached full definition in the 1940s by Kempner diet. The important role of adrenal aldosterone and associates in demonstrating the beneficial ef­ secretion in supporting human hypertension is now fects of a low salt rice diet for treating hypertensive well recognized as are the beneficial effects of patients. It became apparent that the value of rice blockade, especially in low-renin patients who ex­ was wholly related to its sodium content. A rice hibit inappropriate or absolute excesses of aldoste­ diet, or any other stringent low sodium diet, rone secretion. Further definition of the more sub­ greatly improves or completely corrects the hyper­ tle participation of aldosterone and of the factors tension of about ~ or so of all patients with essen­ that control aldosterone secretion in hypertensive subjects are promising areas for further research. tial hypertension. However, what is often forgotten is that little or no benefit accrues to the remaining THE NERVOUS SYSTEM majority of patients. Parallel studies of animal models has demon­ Besides the endocrine and excretory functions of strated the amplifying effect of a high sodium diet the kidney and the influence of dietary sodium on blood pressure and vice versa. Strains of rats and of aldosterone secretion, there has been long­ were developed which are especially sensitive to standing agreement about the important role of the pressor effects of a high sodium diet. In a way, the nervous system in blood pressure control.

• Angiotensin II
• Antihypertonikum
• Dilatation
• Hypertonie
• cardiovascular
• hypertension

• Cardiovascular Center, Division of Cardiology, The New York Hospital—Cornell Medical Center, New York, USA

  John H. Laragh

• Department of Medicine and Department of Research, University Hospital, Basel, Switzerland

  Fritz R. Bühler

• University of Texas Health Science Center at Dallas, Dallas, USA

  Donald W. Seldin

• Parkland Memorial Hospital, Dallas, USA

  Donald W. Seldin

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