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Early Pregnancy Loss

Mechanisms and Treatment

  • Book
  • © 1988

Overview

Editors:
  1. Frank Sharp

    1. Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield, UK

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  2. Richard W. Beard

    1. Department of Obstetrics and Gynaecology, St Mary’s Hospital, London, UK

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (63 chapters)

  1. Front Matter

    Pages i-xviii
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  2. The Clinical Problem

    1. Front Matter

      Pages 1-1
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    2. Clinical associations of recurrent miscarriage

      • R. W. Beard
      Pages 3-8

    3. The epidemiology of repeated abortion

      • E. Alberman
      Pages 9-17

    4. Discussion

      • R. W. Beard
      Pages 19-22

    5. A prospective study of spontaneous abortion

      • L. Regan
      Pages 23-37

    6. Discussion

      • R. W. Beard
      Pages 39-42

    7. Clinical and immunological significance of anti-phospholipid antibodies

      • E. N. Harris
      Pages 43-60

    8. Discussion

      • R. W. Beard
      Pages 61-65

  3. Experimental Models of Early Pregnancy Failure

    1. Front Matter

      Pages 67-67
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    2. Anatomical and immunological aspects of fetal death in the Mus musculus/Mus caroli model of pregnancy failure

      • M. A. Crépeau, S. Yamashiro, B. A. Croy
      Pages 69-83

    3. Discussion

      • W. R. Allen
      Pages 85-87

    4. Genetic aspects of the CBA × DBA/2 and B10 × B10.A models of murine pregnancy failure and its prevention by lymphocyte immunisation

      • G. Chaouat, D. A. Clark, T. G. Wegmann
      Pages 89-102

    5. Discussion

      • W. R. Allen
      Pages 103-104

    6. Effects of feto-maternal major histocompatibility differences on litter size in pigs

      • C. Renard
      Pages 105-118

    7. Discussion

      • W. R. Allen
      Pages 119-121

    8. A non-genetic development defect in trophoblast formation in the horse: immunological aspects of a model of early abortion

      • D. F. Antczak, W. R. Allen
      Pages 123-139

    9. Discussion

      • W. R. Allen
      Pages 141-145

  4. Studies of the Normal and Failing Placenta in Early Pregnancy

    1. Front Matter

      Pages 147-147
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    2. Placental pathology in spontaneous miscarriage

      • D. I. Rushton
      Pages 149-157
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Keywords

About this book

The first few months of any pregnancy are of supreme importance to the success of that pregnancy. This statement is so obvious as to be almost a platitude, yet it must be said that no aspect of pregnancy has been more neglected in the human than the first three months. Little is known of the morphological changes that occur at that time and our knowledge of the mechanisms that control this vital stage of pregnancy is almost non-existent. The explanation for this neglect of what is an obvious area for study is the difficulty of obtaining normal material. It is rare to have material to study from a healthy first trimester pregnancy and the study by Hertig and Rock!l) of early conception found by chance in hysterectomy speci­ mens must be unique. The information that we do have about early pregnancy is mostly gained from animal studies or single miscarriages in humans. Chromosomal defects are common but are not an explanation for the majority of recurrent miscarriages. Obstetricians have hypothesised many causes for this condition and have deve­ loped numerous metQods for treating it, but the studies have been poorly con­ trolled so that our understanding of the cause(s) has not advanced. Treatment of women with a history of recurrent miscarriage by paternal leuco­ cyte infusion (immunotherapy) may be yet another form of treatment that is hailed as a new advance only to be rejected when subject to rigorous testing.

Editors and Affiliations

  • Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield, UK

    Frank Sharp

  • Department of Obstetrics and Gynaecology, St Mary’s Hospital, London, UK

    Richard W. Beard

Bibliographic Information

  • Book Title: Early Pregnancy Loss

  • Book Subtitle: Mechanisms and Treatment

  • Editors: Frank Sharp, Richard W. Beard

  • DOI: https://doi.org/10.1007/978-1-4471-1658-5

  • Publisher: Springer London

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Royal College of Obstetricians and Gynaecologists 1988

  • Softcover ISBN: 978-1-4471-1660-8Published: 07 December 2011

  • eBook ISBN: 978-1-4471-1658-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 442

  • Topics: Obstetrics/Perinatology/Midwifery, Allergology, Immunology, Pediatrics

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