Overview
- Editors:
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Claudio Hetz
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Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA
- Focusses on the potential therapeutic benefits of targeting apoptosis pathways in the context of human disease
- Provides an overview of the emerging roles of BCL-2 family members in different physiological and pathological conditions
- Alternative functions of BCL-2 family proteins
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Table of contents (8 chapters)
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Front Matter
Pages i-xvii
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- Nika N. Danial, Alfredo Gimenez-Cassina, Daniel Tondera
Pages 1-32
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- Diego Rojas-Rivera, Benjamin Caballero, Sebastian Zamorano, Fernanda Lisbona, Claudio Hetz
Pages 33-47
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- Thanh-Trang Vo, Anthony Letai
Pages 49-63
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- Ross T. Weston, Hamsa Puthalakath
Pages 65-77
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- Luca Paoluzzi, Owen A. O’Connor
Pages 79-96
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- Maria Eugenia Soriano, Luca Scorrano
Pages 97-114
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- Heather M. Lamb, J. Marie Hardwick
Pages 115-129
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Back Matter
Pages 143-145
About this book
In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.
Editors and Affiliations
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Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell (CEMC) Millennium Nucleus for Neural Morphogenesis (NEMO), University of Chile, Santiago, Chile
Claudio Hetz
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Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA
Claudio Hetz
About the editor
Claudio Hetz received his BA in Biotechnology Engineering from the University of Chile in 2000. In his PhD work with Claudio Soto at Serono Pharmaceutical Research Institute, Geneva, he showed that Prion pathogenesis involves endoplasmic reticulum stress responses and apoptosis. In 2004 he joined as a postdoctoral fellow Stanley Korsmeyer’s lab at Dana‑Farber Cancer Institute, a pioneer in the apoptosis field. Together they discovered new functions of the BCL‑2 family in organelle physiology. Dr. Hetz followed his projects in Laurie Glimcher’s lab at Harvard. During this period he expanded his studies on neurodegeneration,
addressing the connection between apoptosis and the unfolded protein response in vivo. Since 2007 he is an Assistant Professor at the University of Chile and adjunct professor at Harvard. His lab uses animal models to investigate the signaling responses involved in protein misfolding disorders and the role of the BCL‑2 protein family in stress conditions. He was recently awarded with the TWAS‑ROLAC Young Scientist Prize, also as finalist with the Eppendorf and Science Award in Neurobiology, and other important recognitions.
