Central Nervous System Diseases and Inflammation

1. Front Matter

   Pages i-viii

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2. Microglia: A CNS-Specific Tissue Macrophage

   • Shweta S. Puntambekar, Jonathan M. Doose, Monica J. Carson

   Pages 1-12

3. Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments

   • S. A. Austin, C. K. Combs

   Pages 13-32

4. Pericytes

   • Martin Krüger, Ingo Bechmann

   Pages 33-43

5. Imaging Microglia in the Central Nervous System: Past, Present and Future

   • Dimitrios Davalos, Katerina Akassoglou

   Pages 45-57

6. Cytokines in CNS Inflammation and Disease

   • Malú G. Tansey, Tony Wyss-Coray

   Pages 59-106

7. Arachidonic Acid Metabolites: Function in Neurotoxicity and Inflammation in the Central Nervous System

   • K. Andreasson, T. J. Montine

   Pages 107-129

8. Pattern Recognition Receptors in CNS Disease

   • Pamela A. Carpentier, D'Anne S. Duncan, Stephen D. Miller

   Pages 131-152

9. Central Nervous System Diseases and Inflammation

   • Andrea J. Tenner, Karntipa Pisalyaput

   Pages 153-174

10. Chemokines and Autoimmune Demyelination

    • Michaela Fux, Jason Millward, Trevor Owens

    Pages 175-201

11. Chemokine Actions in the CNS: Insights from Transgenic Mice

    • Marcus Müller, Iain L. Campbell

    Pages 203-219

12. Chemokines and Spinal Cord Injury

    • Maya N. Hatch, Hans S. Keirstead

    Pages 221-233

13. The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System

    • Michelle J. Hickey, Linda N. Stiles, Chris S. Schaumburg

    Pages 235-261

14. CNS Dendritic Cells in Inflammation and Disease

    • Samantha L. Bailey, Stephen D. Miller

    Pages 263-275

15. MHC Class I Expression and CD8 T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain

    • Cornelia Bergmann, Pedro Lowenstein

    Pages 277-306

16. Back Matter

    Pages 307-313

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Up until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood–brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS.

• Antigen
• Chemokine
• Nervous System
• biochemistry
• microbiology
• neurology
• neurotoxicity
• protein
• virology

From the reviews:

"The involvement of the immune system in central nervous system diseases is highlighted in this book, which details important advances in the understanding of certain aspects of neuroinflammation. … This is clearly appropriate for clinicians and researchers who are interested in neuroinflammation in the central nervous system. It also can be a valuable research guide for students who are interested in learning some basics on this topic. … It makes worthwhile contributions to this area." (Christine Maria Rohowsky-Kochan, Doody’s Review Service, September, 2008)

• Center for Immunology Department of Molecular Biology & Biochemistry, University of California, Irvine, USA

  Thomas E. Lane

• Department of Biomedical Sciences, University of California, Riverside, USA

  Monica Carson

• USC Keck School of Medicine Neurology and Pathology, University of Southern California, Los Angeles, USA

  Conni Bergmann

• Department of Neurology, School of Medicine, Stanford, USA

  Tony Wyss-Coray

• Stanford University School of Medicine, Stanford, USA

  Tony Wyss-Coray

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