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Immune Regulation and Immunotherapy in Autoimmune Disease

  • Book
  • © 2007

Overview

Editors:
  1. Jingwu Zhang

    1. Shanghai JiaoTong University School of Medicine, Shanghai, China
      Baylor College of Medicine, Houston, USA

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  • Dr. Zhang is well-known internationally, particularly in the field of multiple sclerosis and T-cell vaccination as a potential treatment of multiple sclerosis

  • He is especially suited to edit such a volume because of his experience and expertise in both basic and clinical aspects of autoimmune disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Immune Regulation and Autoimmune Disease

    1. Front Matter

      Pages 1-1
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    2. Autoimmune Response and Immune Tolerance

      • Ana C. Anderson, Vijay K. Kuchroo
      Pages 3-19

    3. Priming Regulatory T Cells and Antigen-Specific Suppression of Autoimmune Disease

      • Trevor R. F. Smith, Xiaolei Tang, Vipin Kumar
      Pages 20-35

    4. Peripheral T Cell Regulation and Autoimmunity

      • Hong Jiang, Leonard Chess
      Pages 36-55

    5. Anti-Ergotypic Regulation of the Immune Response

      • Francisco J. Quintana, Irun R. Cohen
      Pages 56-65

    6. How B Cells Contribute to Multiple Sclerosis Pathology

      • Kevin C. O'Connor, Sunil V. Cherry, David A. Hafler
      Pages 66-86

    7. Molecular Basis for Induction of Tolerance in Type I Diabetes

      • Sophie Candon, Lucienne Chatenoud, Jean-FranÇois Bach
      Pages 87-120

    8. Co-stimulation Regulation of Immune Tolerance and Autoimmunity

      • Chen Dong, Roza Nurieva, Natalia Martin-Orozco
      Pages 121-138

    9. Invariant NKT Cells and Immune Regulation in Multiple Sclerosis

      • Takashi Yamamura
      Pages 139-151

    10. CD4+CD25+ Regulatory T Cells in Autoimmune Disease

      • Adam P. Kohm, Stephen D. Miller
      Pages 152-170

    11. Immunopathogenesis of Multiple Sclerosis: Overview

      • Til Menge, Bernhard Hemmer, Stefan Nessler, Dun Zhou, Bernd C. Kieseier, Hans-Peter Hartung
      Pages 171-187

    12. Viral Infection and Multiple Sclerosis

      • Elizabeth L. Williams, Steven Jacobson
      Pages 188-213

    13. Multiple Sclerosis Pathology During Early and Late Disease Phases: Pathogenic and Clinical Relevance

      • Claudia F. Lucchinetti
      Pages 214-264

    14. CD8+ T Cells in Multiple Sclerosis

      • Manuel A. Friese, Lars Fugger
      Pages 265-285

  3. Novel Immunotherapeutic Strategies and Emerging Treatments

    1. Front Matter

      Pages 288-288
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    2. Review of Novel Immunotherapeutic Strategies for MS

      • Heinz Wiendl, Reinhard Hohlfeld
      Pages 289-338

    3. T Cell Vaccination in Autoimmune Disease

      • Sheri M. Skinner, Ying C. Q. Zang, Jian Hong, Jingwu Z. Zhang
      Pages 339-368

    4. Trivalent T Cell Receptor Peptide Vaccine for Treatment of Multiple Sclerosis Targets Predominant V Genes Widely Implicated in Autoimmune Diseases and Allergy

      • Arthur A. Vandenbark, Nicole E. Culbertson
      Pages 369-408

    5. Nonmyeloablative Stem Cell Transplantation for Multiple Sclerosis

      • Richard K. Burt, Yvonne Loh, Larissa Verda
      Pages 409-424
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Keywords

About this book

This book critically reviews both clinical and immunological aspects of auto- mune disease with a strong emphasis on multiple sclerosis (MS). Research in MS is one of the fastest-developing areas in modern medicine. It employs some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. It is an area in which research findings are being actively translated into treatment strategies. Advances in this area have both clinical and scientific implications for other autoimmune conditions that share many similarities with MS. The book, which comprises 24 chapters contributed by experts and thought leaders in the field, is designed to provide new insights into two arenas: our current understanding of autoimmune mechanisms and immune regulation and the latest developments in immunotherapy. This book is intended for both researchers and clinicians. Its purpose is not only to provide a comprehensive review on the recent advances in the two arenas m- tioned above but also to reflect the current opinions or concepts that influence our thinking about the disease mechanisms and our way of treating MS patients. Many of these issues have emerged from recent studies and are somewhat contradictory to traditional thinking. For example, recent studies have indicated that MS is more heterogeneous in many aspects than traditionally thought. Pathologically, in ad- tion to demyelination and inflammation, there is axonal loss or damage detectable in the central nervous system (CNS) lesions.

Editors and Affiliations

  • Shanghai JiaoTong University School of Medicine, Shanghai, China

    Jingwu Zhang

  • Baylor College of Medicine, Houston, USA

    Jingwu Zhang

Bibliographic Information

  • Book Title: Immune Regulation and Immunotherapy in Autoimmune Disease

  • Editors: Jingwu Zhang

  • DOI: https://doi.org/10.1007/978-0-387-36003-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2007

  • Hardcover ISBN: 978-0-387-36002-7Published: 26 January 2007

  • Softcover ISBN: 978-1-4419-4209-8Published: 29 October 2010

  • eBook ISBN: 978-0-387-36003-4Published: 25 January 2007

  • Edition Number: 1

  • Number of Pages: XVI, 570

  • Number of Illustrations: 57 b/w illustrations, 11 illustrations in colour

  • Topics: Immunology, Microbiology, Infectious Diseases, Virology, Pharmacology/Toxicology

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