Overview
- Editors:
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Leonidas C. Platanias
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Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, USA
- To date there has not been a book published that covers both the basic science and translational/clinical research in the field of cytokines in malignancies
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Table of contents (15 chapters)
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Front Matter
Pages i-xiii
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Basic Science Research
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- Anupama Gururaj, Rakesh Kumar
Pages 1-14
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- Thomas T. Murooka, Sarah E. Ward, Eleanor N. Fish
Pages 15-44
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- Simrit Parmar, Leonidas C. Platanias
Pages 45-68
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- Georgios V. Georgakis, Anas Younes
Pages 69-102
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- Bharat B. Aggarwal, Yasunari Takada
Pages 103-127
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- Virginia Kaklamani, Boris Pasche
Pages 129-156
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- Brian Zhu, Natasha Kyprianou
Pages 157-173
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- Jennifer A. Doll, Gerald A. Soff
Pages 175-204
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Clinical and Translational Research
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- Stergios Moschos, Sai Varanasi, John M. Kirkwood
Pages 207-241
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- John W. Eklund, Timothy M. Kuzel
Pages 263-287
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- Farhad Ravandi, Partow Kebriaei
Pages 313-331
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- Robin Parihar, William E. Carson III
Pages 353-373
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Back Matter
Pages 375-377
About this book
Dramatic advances have occurred over the last few years in the research field of cancer biology. There has been a constant accumulation of important new information, resulting in a gradual transformation on the perceptions that exist among scientists regarding mechanisms by which the malignant phenotype develops. The recent developments in cancer research have also had a substantial impact in efforts towards the development of new cancer therapies. One of the most explosive and rapidly advancing research areas has been the area of cytokines and cancer. Many perceptions have changed from the original discovery, decades ago, of the interferon, to the current state of the art cytokine research. It is now well recognized that many cytokines play important roles in normal cellular functions, while some of them have prominent roles in the pathophysiology of cancer. It is also now firmly established that several cytokines promote the growth of cancer cells, while others act as suppressors of malignant cell proliferation. The importance of the cytokine signaling field in cancer is reflected by the development of multiple treatments that have been introduced in clinical oncology over the last few years. Understanding the physiological functions of cytokines, as well as their precise roles in the pathogenesis of certain malignancies, is extremely important in the current clinical era.
Editors and Affiliations
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Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, USA
Leonidas C. Platanias
