Overview
- Editors:
-
-
Abel Lajtha
-
Nathan S. Kline Institute for Psychiatric Research, Orangeburg
-
Naren L. Banik
-
Medical University of South Carolina, Charleston
Access this book
Other ways to access
Table of contents (18 chapters)
-
Front Matter
Pages ii-xii
-
-
-
- Donald C. Shields, Naren L. Banik
Pages 25-45
-
- Dieter Brömme, Suzana Petanceska
Pages 47-61
-
- Darrel E. Goll, Valery F. Thompson, Hongqi Li, Jinyang Cong
Pages 63-73
-
- Dwaine F. Emerich, Raymond T. Bartus
Pages 75-84
-
- T.R. Shearer, H. Ma, M Shih, K.J. Lampi, C. Fukiage, M. Azuma
Pages 85-99
-
- Carmela R. Abraham, Franchot Slot
Pages 101-116
-
- Mark P. Mattson, Sic L. Chan
Pages 117-135
-
- Maria E. Figueiredo-Pereira, Patricia Rockwell
Pages 137-153
-
- Neville Marks, Martin J. Berg
Pages 155-178
-
- Jörg B. Schulz, Michael A. Moskowitz
Pages 179-187
-
-
- Swapan K. Ray, Denise C. Matzelle, Gloria G. Wilford, Lawrence F. Eng, Edward L. Hogan, Naren L. Banik
Pages 199-226
-
- Vito Turk, Janko Kos, Gregor Guncar, Boris Turk
Pages 227-240
-
- Peter A. Forsyth, Dylan R. Edwards, Marc A. LaFleur, V. W. Yong
Pages 241-268
-
-
- Hahn-Jun Lee, Koichi Suzuki, Takaomi C Saido
Pages 283-296
-
Back Matter
Pages 297-302
About this book
Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.
Editors and Affiliations
-
Nathan S. Kline Institute for Psychiatric Research, Orangeburg
Abel Lajtha
-
Medical University of South Carolina, Charleston
Naren L. Banik
About the editors
Dr. Lajtha is the editor of the Journal of Neurochemical Research.