Cancer Precursors

1. Front Matter

   Pages i-xx

   PDF

2. Site-Specific Precancerous Conditions

   1. Introduction

      • Thomas E. Rohan, Eduardo L. Franco

      Pages 1-3

3. Biological Basis of Carcinogenesis

   1. Front Matter

      Pages 5-5

      PDF

   2. Mechanisms and Biological Markers of Carcinogenesis

      • Regina M. Santella

      Pages 7-19

   3. Morphology of Cancer Precursor Lesions

      • Michael B. Cohen

      Pages 20-29

4. Issues Related to Measurement and Interpretation of Cancer Precursors

   1. Front Matter

      Pages 31-31

      PDF

   2. Collection, Processing, and Analysis of Preneoplastic Specimens

      • Neil Caporaso, Jim Vaught

      Pages 33-45

   3. Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints

      • Arthur Schatzkin

      Pages 46-59

   4. Assessing Epidemiological Relations and the Role of Measurement Errors

      • Eduardo L. Franco, Thomas E. Rohan

      Pages 60-74

5. Site-Specific Precancerous Conditions

   1. Front Matter

      Pages 75-75

      PDF

   2. Upper Aerodigestive Tract

      • R. Sankaranarayanan, Thara Somanathan

      Pages 77-95

   3. Esophagus

      • Thomas L. Vaughan

      Pages 96-116

   4. Stomach

      • Pelayo Correa

      Pages 117-126

   5. Colon and Rectum

      • John A. Baron

      Pages 127-150

   6. Anus

      • Joel M. Palefsky

      Pages 151-163

   7. Liver

      • Morris Sherman, Ian Wanless

      Pages 164-185

   8. Pancreas

      • Ralph H. Hruban, Christine Iacobuzio-Donahue, Michael Goggins

      Pages 186-200

   9. Lung

      • Pamela M. Marcus, William D. Travis

      Pages 201-219

   10. Skin

       • Richard P. Gallagher, Tim K. Lee

       Pages 220-231

   11. Breast

       • Thomas E. Rohan, Rita A. Kandel

       Pages 232-248

Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process.

• Cancer precursors
• cancer
• chemoprevention
• detection
• epidemiological
• epidemiology
• molecular epidemiology
• prevention
• prevention strategies
• screening

From the reviews:

"Drs. Franco and Rohan bring together a timely and comprehensive set of reviews describing the biologic basis of carcinogenesis, issues related to measurement and interpretation of cancer precursors, site specific precancerous conditions, and control of cancer precursors …The book has several important strengths, most notably the wealth of current information on cancer precursors and related topics provided by an impressive cast of cancer researchers. … it effectively provides specific and compelling reasons for studying cancer precursors, the most up-to-date and comprehensive collection of reviews on the topic, and a realistic picture of the complexities facing research of cancer precursors.”      —American Journal of Epidemiology

"In this book, Drs. Franco and Rohan have succeeded in preparing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer precursors. They have enlisted experts in the field who have contributed authoritative chapters to a wide variety of cancers with emphasis on the etiology and natural history, including the role of environmental and heritable factor that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as clasical cellular pathology, providing a fuller understanding of the casual events and mechanisms that initiate the carcinogenic process."
-From the Foreward by Joseph F. Fraumeni, Jr., M.D., M.S.
Director, Division of Cancer Epidemiology and Genetics
National Cancer Institute
National Institutes of Health
Rockville, MD

"This first edition text presents epidemiological data on the importance of precursor lesions at all the major anatomical sites. … The strongest and most interesting section of the book is part three, which deals with precursor lesions at each of the important anatomical sites. …The most interesting chapters were those that sought to integrate the epidemiology, pathology and molecular biology of the disease … . Overall, I found this book made interesting reading and certainly some chapters would serve as an excellent reference text." (R Ward, Cancer Forum, Vol. 26 (3), 2002)

• Departments of Oncology and Epidemiology, McGill University, Montreal, Canada

  Eduardo L. Franco

• Division of Cancer Epidemiology, McGill University, Montreal, Canada

  Eduardo L. Franco

• Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, USA

  Thomas E. Rohan

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