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Microarrays

Preparation, Microfluidics, Detection Methods, and Biological Applications

  • Book
  • © 2009

Overview

Editors:
  1. Kilian Dill

    1. CombiMatrix Corporation, Inc. 6500 Harbour Heights Parkway, Mukilteo, USA

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  2. Robin Hui Liu

    1. Osmetech Molecular Diagnostics, Pasadena, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Piotr Grodzinski

    1. National Institutes of Health National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Application of combinatorial chemistry to sensor materials
  • No competition whatsoever
  • One of the first books in the series Integrated Microanalytical Systems, recently renamed Integrated Analytical Systems
  • Includes supplementary material: sn.pub/extras

Part of the book series: Integrated Analytical Systems (ANASYS)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Overview and New Detection Method

    1. The Current Status of DNA Microarrays

      • Leming Shi, Roger G. Perkins, Weida Tong
      Pages 3-24

    2. Electrochemical Detection on Microarrays

      • Kilian Dill, Andrey Ghindilis
      Pages 25-34

  3. Fluidic Manipulation and Microarrays

    1. Fully Integrated Microfluidic Device for Direct Sample-to-Answer Genetic Analysis

      • Robin H. Liu, Piotr Grodzinski
      Pages 37-65

    2. Integrated Microfluidic Devices for Automated Microarray-Based Gene Expression and Genotyping Analysis

      • Robin H. Liu, Mike Lodes, H. Sho Fuji, David Danley, Andrew McShea
      Pages 67-93

  4. Statistical Data Evaluation on Microarrays

    1. Intensity Concentration Relationships for Electrochemical Detection

      • Mervyn Thomas
      Pages 97-117

  5. Applications

    1. Genotyping Arrays

      • Michael J. Lodes, Dominic Suciu, David Danley, Andrew McShea
      Pages 121-138

    2. Peptide-Based Microarray

      • Resmi C. Panicker, Hongyan Sun, Grace Y. J. Chen, Shao Q. Yao
      Pages 139-167

    3. Protein Microarrays for the Detection of Biothreats

      • Amy E. Herr
      Pages 169-190

    4. Photo-Generation of Carbohydrate Microarrays

      • Gregory T. Carroll, Denong Wang, Nicholas J. Turro, Jeffrey T. Koberstein
      Pages 191-210

    5. Expression Profiling Using Microfluidic Living Cell Arrays

      • Kevin R. King, Martin L. Yarmush, Arul Jayaraman
      Pages 211-226

    6. New Approaches to the Synthesis of Addressable Microarray Molecular Libraries

      • Karl Maurer, Kevin D. Moeller
      Pages 227-246

    7. eSensor®A Microarray Technology Based on Electrochemical Detection of Nucleic Acids and Its Application to Cystic Fibrosis Carrier Screening

      • Michael R. Reed, William A. Coty
      Pages 247-260

  6. Future Improvements in Microarray Sensing

    1. Use of Redox Enzymes for the Electrochemical Detection of Sequence-Specific DNA and Immunochemical Entities

      • Kilian Dill, Andrey Ghindilis
      Pages 263-270

    2. Biochip Platforms for DNA Diagnostics

      • Anil K. Deisingh, Adilah Guiseppi-Wilson, Anthony Guiseppi-Elie
      Pages 271-297

    3. MagArray Biochips for Protein and DNA Detection with Magnetic Nanotags: Design, Experiment, and Signal-to-Noise Ratio

      • Sebastian J. Osterfeld, Shan X. Wang
      Pages 299-314

    4. Bar Coding Platforms for Nucleic Acid and Protein Detection

      • Uwe R. Müller
      Pages 315-338

    5. Electrochemical Nanoparticle-Based Sensors

      • Joseph Wang
      Pages 339-353

  7. Back Matter

    Pages 355-356
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Keywords

About this book

Combinatorial chemistry is used to find materials that form sensor microarrays. This book discusses the fundamentals, and then proceeds to the many applications of microarrays, from measuring gene expression (DNA microarrays) to protein-protein interactions, peptide chemistry, carbodhydrate chemistry, electrochemical detection, and microfluidics.

Reviews

From the reviews:

"Microarray technology is not without its challenges and limitations … this book highlight novel approaches that may address some of those issues and offer suggestions of new strategies on the horizon. … I found many of the topics in the book to be interesting … . it has a considerable amount of useful material for someone who … is looking for a broader perspective on applications. It will also be useful to those focused on electrochemical detection and microfluidics in microarrays." (Peter Wentzell, Journal of the American Chemical Society, Vol. 131 (36), 2009)

Editors and Affiliations

  • CombiMatrix Corporation, Inc. 6500 Harbour Heights Parkway, Mukilteo, USA

    Kilian Dill

  • Osmetech Molecular Diagnostics, Pasadena, USA

    Robin Hui Liu

  • National Institutes of Health National Cancer Institute, Bethesda, USA

    Piotr Grodzinski

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