Overview
- Chapters focus on the cellular and molecular mechanisms of various small-molecule compounds and inhibitors that target proteins that regulate the proteasome, ubiquitin ligases, ubiquitination pathway, and aggresome pathway in cancer
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.
Bibliographic Information
Book Title: Modulation of Protein Stability in Cancer Therapy
Editors: Eric Rubin, Kathleen Sakamoto
DOI: https://doi.org/10.1007/978-0-387-69147-3
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2009
Hardcover ISBN: 978-0-387-69143-5
Softcover ISBN: 978-1-4419-2401-8
eBook ISBN: 978-0-387-69147-3
Edition Number: 1
Number of Pages: X, 165
Number of Illustrations: 35 b/w illustrations
Topics: Cancer Research, Medical Microbiology, Human Genetics, Immunology, Biochemistry, general