Editors:
- Ties together the latest research into the workings of the kinetochore/centromere complex and neocentromeres; including what is known about their structure, how they function, how they are regulated,
- their involvement in the etiology of cancer, and how these structures might be targeted in cancer therapeutics
- Includes supplementary material: sn.pub/extras
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Table of contents (15 chapters)
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Front Matter
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Back Matter
About this book
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. “The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
Editors and Affiliations
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Dipto. Oncologia Sperimentale, Istituto Europeo di Oncologia, Milano, Italy
Peter De Wulf
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Animal & Population Biology, Inst. Cell & Molecular Biology, University of Edinburgh, Edinburgh, United Kingdom
William C. Earnshaw
Bibliographic Information
Book Title: The Kinetochore:
Book Subtitle: From Molecular Discoveries to Cancer Therapy
Editors: Peter De Wulf, William C. Earnshaw
DOI: https://doi.org/10.1007/978-0-387-69076-6
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2009
Hardcover ISBN: 978-0-387-69073-5
Softcover ISBN: 978-1-4419-2398-1
eBook ISBN: 978-0-387-69076-6
Edition Number: 1
Number of Pages: XIII, 516
Topics: Cancer Research, Cell Biology, Medical Microbiology, Molecular Medicine, Human Genetics, Virology