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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

  • Book
  • © 2007

Overview

Editors:
  1. Peter Csermely

    1. Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

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  2. László Vígh

    1. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

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    You can also search for this editor in PubMed   Google Scholar

  • Chapter Summaries
  • Detailed Illustrations

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 594)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Protein Misassembly

    • R. John Ellis
    Pages 1-13

  3. The Cellular “Networking” of Mammalian Hsp27 and Its Functions in the Control of Protein Folding, Redox State and Apoptosis

    • André-Patrick Arrigo
    Pages 14-26

  4. Molecular Interaction Network of the Hsp90 Chaperone System

    • Rongmin Zhao, Walid A. Houry
    Pages 27-36

  5. Organization of the Functions and Components of the Endoplasmic Reticulum

    • Yuichiro Shimizu, Linda M. Hendershot
    Pages 37-46

  6. Molecular Crime and Cellular Punishment

    • Marie-Pierre Hinault, Pierre Goloubinoff
    Pages 47-54

  7. Chaperones as Parts of Cellular Networks

    • Peter Csermely, Csaba Söti, Gregory L. Blatch
    Pages 55-63

  8. Chaperones as Parts of Organelle Networks

    • György Szabadkai, Rosario Rizzuto
    Pages 64-77

  9. Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways

    • Julius Anckar, Lea Sistonen
    Pages 78-88

  10. Chaperone Regulation of the Heat Shock Protein Response

    • Richard Voellmy, Frank Boellmann
    Pages 89-99

  11. Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways

    • Sébastien Ian Nadeau, Jacques Landry
    Pages 100-113

  12. Membrane-Regulated Stress Response

    • László Vígh, Zsolt Török, Gábor Balogh, Attila Glatz, Stefano Piotto, Ibolya Horváth
    Pages 114-131

  13. Beyond the Lipid Hypothesis

    • Scott A. L. Hayward, Patricia A. Murray, Andrew Y. Gracey, Andrew R. Cossins
    Pages 132-142

  14. Trehalose As a “Chemical Chaperone”

    • John H. Crowe
    Pages 143-158

  15. Chaperones As Part of Immune Networks

    • Zoltán Prohászka
    Pages 159-166

  16. The Stress of Misfolded Proteins

    • Heather R. Brignull, James F. Morley, Richard I. Morimoto
    Pages 167-189

  17. Hsp90 and Developmental Networks

    • Suzannah Rutherford, Jennifer R. Knapp, Peter Csermely
    Pages 190-197

  18. Back Matter

    Pages 199-201
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Keywords

About this book

We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes. The volume starts with an introduction to the concept of molecular chaperones in their original sense: R. John Ellis, the founder of the chaperone concept describes chaperones as mediators of correct assembly and/or misassembly of other macromolecular complexes. This sets the tone of the book, where later chapters give detailed examples of the richness of chaperone ac­ tion by hundreds of other proteins and membrane structures. The reader will learn the role of chaperone classes such as Hsp27 or Hsp90, the action of highly organized chaperone networks in various cellular compartments such as the ER or mitochondrial/ER networks as well as the molecular details of the signaling mechanisms leading to chaperone induction during stress. Various special stress defense mechanisms against oxidative stress or dryness will also be covered. Membranes comprise a surprising mixture of stability and dynamics in the cell. Their role in the regulation of the stress response has been accepted only slowly in the field. Two chapters summarize this important aspect of the stress response showing the importance of membrane hyperstructures, lipid species composition, protein/ membrane interactions and cold adaptation.

Editors and Affiliations

  • Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

    Peter Csermely

  • Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    László Vígh

Bibliographic Information

  • Book Title: Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

  • Editors: Peter Csermely, László Vígh

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-39975-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007

  • Hardcover ISBN: 978-0-387-39974-4Published: 12 December 2006

  • Softcover ISBN: 978-1-4419-2297-7Published: 23 November 2010

  • eBook ISBN: 978-0-387-39975-1Published: 09 August 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVIII, 201

  • Number of Illustrations: 54 b/w illustrations, 1 illustrations in colour

  • Topics: Biochemistry, general, Cell Biology, Biological and Medical Physics, Biophysics, Immunology

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