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Interstitial Fibrosis in Heart Failure

  • Book
  • © 2005

Overview

Editors:
  1. Francisco J. Villarreal

    1. Department of Medicine, University of California, San Diego School of Medicine, San Diego, USA

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  • Focused volume on cardiac extracellular matrix structure
  • This topic normally covered as a chapter in larger heart failure texts
  • Provides more in-depth information
  • There is currently no direct competition to this text

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 253)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Architecture of the Normal and Remodeled Heart

    1. The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix

      • Ian LeGrice, Adéle Pope, Bruce Smaill
      Pages 3-21

    2. Extracellular Matrix and Cardiac Remodeling

      • Bodh I. Jugdutt
      Pages 23-55

    3. Pro-Inflammatory Cytokines and Cardiac Extracellular Matrix: Regulation of Fibroblast Phenotype

      • R. Dale Brown, M. Darren Mitchell, Carlin S. Long
      Pages 57-81

    4. Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts

      • Sara A. Epperson, Åsa B. Gustafsson, Annette M. Gonzalez, Sonia Villegas, J. Gary Meszaros, Laurence L. Brunton
      Pages 83-97

  3. Diagnostic Tools for the Identification of Myocardial Fibrosis and Changes in Ventricular Mechanics

    1. Serum Markers of Fibrillar Collagen Metabolism in Cardiac Diseases

      • Javier Diez
      Pages 101-113

    2. Ultrasonic Characterization of the Myocardium

      • Mark R. Holland, Samuel A. Wickline
      Pages 115-148

    3. The Mechanics of the Fibrosed/Remodeled Heart

      • Robert C. Gorman, Benjamin M. Jackson, Joseph H. Gorman, L. Henry Edmunds Jr.
      Pages 149-163

  4. Pathophysiology of Cardiac Remodeling and Fibrosis

    1. Renin Angiotensin Aldosterone System and Cardiac Extracellular Matrix

      • Yao Sun, Karl T. Weber
      Pages 167-180

    2. Matrix Metalloproteinases and Myocardial Remodeling

      • English Chapman, Francis G. Spinale
      Pages 181-196

    3. Cardiac Mast Cells as Mediators of Ventricular Remodeling

      • Joseph S. Janicki, Gregory L. Brower, Amanda L. Chancey, Mary F. Forman, Lynetta J. Jobe
      Pages 197-209

  5. Matrix Metalloproteinasses in Cardiac Remodeling

    1. Turmoil in the Cardiac Myocyte: Acute Intracellular Activation of Matrix Metalloproteinases

      • Manoj M. Lalu, Hernando Leon, Richard Schulz
      Pages 213-237

    2. Regulation of Cardiac Extracellular Matrix Remodeling Following Myocardial Infarction.

      • Jack P. M. Cleutjens
      Pages 239-251

    3. Experimental Models of MMP Activation: Ventricular Volume Overload

      • Baljit S. Walia, Stephen C. Jones, Jianming Hao, Ian M. C. Dixon
      Pages 253-271

  6. Prospect for Therapy of the Fibrosed Heart

    1. Targets for Pharmacological Modulation of Cardiac Fibrosis

      • Lindsay Brown, Vincent Chan, Andrew Fenning
      Pages 275-310

    2. Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium

      • Guillermo Torre-Amione, Cynthia K. Wallace, O. H. Frazier
      Pages 311-328

    3. Molecular Strategies for the Prevention of Cardiac Fibrosis

      • Ramareddy V. Guntaka, Karl T. Weber
      Pages 329-341

    4. Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover

      • Hiroshi Ashikaga, Francisco J. Villarreal
      Pages 343-354

    5. Therapeutic Potential of TIMPs in Heart Failure

      • Suresh C. Tyagi
      Pages 355-363

  7. Back Matter

    Pages 365-373
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Keywords

About this book

Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis.

This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.

Editors and Affiliations

  • Department of Medicine, University of California, San Diego School of Medicine, San Diego, USA

    Francisco J. Villarreal

About the editor

Francisco J. Villarreal, M.D., Ph.D. is a Professor in the Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California.

Bibliographic Information

  • Book Title: Interstitial Fibrosis in Heart Failure

  • Editors: Francisco J. Villarreal

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/b99419

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag New York 2005

  • Hardcover ISBN: 978-0-387-22824-2Published: 08 September 2004

  • Softcover ISBN: 978-1-4419-1983-0Published: 29 November 2010

  • eBook ISBN: 978-0-387-22825-9Published: 17 December 2005

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XIV, 373

  • Number of Illustrations: 93 b/w illustrations

  • Topics: Cardiology, Cardiac Surgery

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