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V(D)J Recombination

  • Book
  • © 2009

Overview

Editors:
  1. Pierre Ferrier

    1. Centre d’Immunologie de Marseille-Luminy, Université d’Aix Marseille, Marseille, France

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes

    • Patrick C. Swanson, Sushil Kumar, Prafulla Raval
    Pages 1-15

  3. Regulation of RAG Transposition

    • Adam G. W. Matthews, Marjorie A. Oettinger
    Pages 16-31

  4. Recent Insights into the Formation of RAG-Induced Chromosomal Translocations

    • Vicky L. Brandt, David B. Roth
    Pages 32-45

  5. V(D)J Recombination Deficiencies

    • Jean-Pierre de Villartay
    Pages 46-58

  6. Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene Regulation

    • Daniel J. Bolland, Andrew L. Wood, Anne E. Corcoran
    Pages 59-72

  7. Genetic and Epigenetic Control of V Gene Rearrangement Frequency

    • Ann J. Feeney
    Pages 73-81

  8. Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Chain Repertoire in Man and Mouse

    • Evelyne Jouvin-Marche, Patrizia Fuschiotti, Patrice Noël Marche
    Pages 82-92

  9. Germline Transcription: A Key Regulator of Accessibility and Recombination

    • Iratxe Abarrategui, Michael S. Krangel
    Pages 93-102

  10. Dynamic Regulation of Antigen Receptor Gene Assembly

    • Lance R. Thomas, Robin Milley Cobb, Eugene M. Oltz
    Pages 103-115

  11. Molecular Genetics at the T-Cell Receptor β Locus: Insights into the Regulation of V(D)J Recombination

    • Marie Bonnet, Pierre Ferrier, Salvatore Spicuglia
    Pages 116-132

  12. Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development

    • Kristen Johnson, Karen L. Reddy, Harinder Singh
    Pages 133-147

  13. Regulation of V(D)J Recombination by E-Protein Transcription Factors

    • Mary Elizabeth Jones, Yuan Zhuang
    Pages 148-156

  14. Temporal and Spatial Regulation of V(D)J Recombination: Interactions of Extrinsic Factors with the RAG Complex

    • Yun Liu, Li Zhang, Stephen Desiderio
    Pages 157-165

  15. V(D)J Recombination: Of Mice and Sharks

    • Ellen Hsu
    Pages 166-179

  16. Normal and Pathological V(D)J Recombination: Contribution to the Understanding of Human Lymphoid Malignancies

    • Saïda Dadi, Sandrine Le Noir, Vahid Asnafi, Kheïra Beldjord, Elizabeth A. Macintyre
    Pages 180-194

  17. Back Matter

    Pages 195-199
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Keywords

About this book

v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho­ cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.

Editors and Affiliations

  • Centre d’Immunologie de Marseille-Luminy, Université d’Aix Marseille, Marseille, France

    Pierre Ferrier

About the editor

PIERRE FERRIER is a Principal Investigator and Research Director at the

Centre d’Immunologie de Marseille-Luminy (CIML), France. He has also worked

as a Director of Marseille-Nice Genopole, a local consortium of more than twenty

laboratories aimed at developing high-throughput research techniques in genomics.

Main research interests include the analysis of the molecular mechanisms responsible

for the control of gene expression and recombination programs during hematopoietic

cell development and pathogenesis. He is a member of several national and international

scientific organizations including the Institut National de la Santé et de la

Recherche Médicale (Inserm), the Agence Nationale de la Recherche (ANR), the

Association pour la Recherche sur le Cancer (ARC), the Human Frontier Science

Program Organization (HFSPO), and the Université Virtuelle Médicale de Monaco

(UVMM). Pierre Ferrier received his academic degrees from Montpellier (MD) and

Marseille (PhD) Universities, France. He was a post-doctoral fellow (1986-90) in

the laboratory of Prof. F.W. Alt at the Columbia University College of Physicians

and Surgeons, New York, NY, USA.

Bibliographic Information

  • Book Title: V(D)J Recombination

  • Editors: Pierre Ferrier

  • DOI: https://doi.org/10.1007/978-1-4419-0296-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2009

  • Hardcover ISBN: 978-1-4419-0295-5Published: 22 June 2009

  • Softcover ISBN: 978-1-4939-0124-1Published: 03 December 2014

  • eBook ISBN: 978-1-4419-0296-2Published: 24 December 2009

  • Edition Number: 1

  • Number of Pages: XVII, 199

  • Additional Information: Jointly published with Landes Bioscience

  • Topics: Biomedicine general

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