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  • Book
  • © 2009

Apoptotic Chromatin Changes

Authors:

  1. Gáspár Bánfalvi

    1. Institute of Biology and Ecology, University of Debrecen, Debrecen 4010

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  • The first to show the dynamic change of chromatin structures in a cell cycle-dependent manner
  • Describes the intermediates of chromatin condensation
  • Distinguishes between chromatin and chromosomal forms
  • Describes how round shaped chromatin bodies, the first interphase chromosomes are converted to linear chromosomes
  • Proves the linear attachment of chromosomes including interphase and metaphase chromosomes
  • Visualizes chromatin changes upon genotoxic treatment (chemical carcinogenesis, heavy metal, irradiation)
  • Provides the reader with additional information in the glossary section
  • Helps the reader with a detailed list of abbreviations
  • Helps to understand three dimensionality and seemingly difficult terms such as supercoiling
  • Demonstrates that Drosophila chromosomes consist of smaller units called rodlets
  • Demonstrates that the nucleosomal arrangement of Drosophila chromatin consist of meandering loops
  • Reevaluates data of nucleosomal strings and provides a plectonemic chromatin model of chromosome condensation in Drosophila cells

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-XII
    PDF

  2. DNA Empire

    • Gáspár Bánfalvi
    Pages 1-30

  3. Structural Organization of DNA

    • Gáspár Bánfalvi
    Pages 31-124

  4. Chromatin Condensation

    • Gáspár Bánfalvi
    Pages 125-202

  5. Apoptosis

    • Gáspár Bánfalvi
    Pages 203-292

  6. Apoptotic Chromatin Changes

    • Gáspár Bánfalvi
    Pages 293-364

  7. Back Matter

    Pages 365-412
    PDF
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About this book

The writing of this book is based on: 1. earlier experience writing textbooks for biology students with a university-level background in biology and biochemistry with many (>200) ?gures in these books (in Hungarian), 2. and on the necessity to present university lectures as power point presentations to catch the interest of s- dents. The author realizes that young readers who were grown up in an information society are relactant to read too much unless they have to take exams. Even then they prefer books which contain illustrations for a better understanding. In collaboration with colleagues, referees and members of the publishing staff an extensive set of photographs and illustrations were collected to provide a graphic follow-up to the text. Further aids for the student, instructor and the curious reader are provided by summaries, extensive sets of readings and references for each chapter, a glossary of the terms, list of abbreviations and a DVD with a red-blue eyeglass to visualize three dimensional chromatin structures. The reader could ask: Why another book on apoptosis? The answer to the question is related to the de?nition of the process. The term apoptosis has been introduced to describe typical morphological changes leading to controlled se- destruction of cells. The ?rst demonstrated biochemical feature of this type of cell death was internucleosomal fragmentation, which was occasionally preceded by the generation of large DNA fragments.
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Keywords

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Authors and Affiliations

  • Institute of Biology and Ecology, University of Debrecen, Debrecen 4010

    Gáspár Bánfalvi

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