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The Biology of Skeletal Metastases

  • Book
  • © 2004

Overview

Editors:
  1. Evan T. Keller

    1. University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, USA

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  2. Leland W. K. Chung

    1. Emory University School of Medicine, Emory University, Atlanta, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Skeletal metastases are both a common and devastating consequence of a spectrum of cancers.
  • Significant advances have occurred in our understanding of the pathobiology of this process.
  • This book provides a comprehensive review of current investigative findings and their clinical implications

Part of the book series: Cancer Treatment and Research (CTAR, volume 118)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxi
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  2. The Basic Biology of Metastasis

    • Victoria L. Robinson, Eric C. Kauffman, Mitchell H. Sokoloff, Carrie W. Rinker-Schaeffer
    Pages 1-21

  3. Clinical Aspects of Bone Metastases in Prostate Cancer

    • Shi-Ming Tu, Sue-Hwa Lin
    Pages 23-46

  4. Animal Models of Bone Metastasis

    • Thomas J. Rosol, Sarah H. Tannehill-Gregg, Stephanie Corn, Abraham Schneider, Laurie K. McCauley
    Pages 47-81

  5. MIP-1 Alpha and Myeloma Bone Disease

    • G. David Roodman, Sun Jin Choi
    Pages 83-100

  6. Type I Collagen-Mediated Changes in Gene Expression and Function of Prostate Cancer Cells

    • Jeffrey Kiefer, Angela Alexander, Mary C. Farach-Carson
    Pages 101-124

  7. PTHrP and Skeletal Metatasis

    • Laurie K. McCauley, Abraham Schneider
    Pages 125-147

  8. OPG, RANKL, and RANK in Cancer Metastasis: Expression and Regulation

    • Julie M. Brown, Jian Zhang, Evan T. Keller
    Pages 149-172

  9. Matrix Metalloproteinaes and Bone Metastasis

    • R. Daniel Bonfil, Pamela Osenkowski, Rafael Fridman, Michael L. Cher
    Pages 173-195

  10. Endothelins in Bone Cancer Metastases

    • Theresa A. Guise, Khalid S. Mohammad
    Pages 197-212

  11. Bisphosphonate Actions on Bone and Visceral Metastases

    • Toshiyuki Yoneda, Nobuyuki Hashimoto, Toru Hiraga
    Pages 213-229

  12. Gene Therapy for Prostate Cancer Bone Metastasis

    • Chia-Ling Hsieh, Hiroyuki Kubo, Leland W. K. Chung
    Pages 231-290

  13. Cancer Cells Homing to Bone: The Significance of Chemotaxis and Cell Adhesion

    • Carlton R. Cooper, Robert A. Sikes, Brian E. Nicholson, Yan-Xi Sun, Kenneth J. Pienta, Russell S. Taichman
    Pages 291-309

  14. Histological, Immunophenotypic and Histomorphometric Characterization of Prostate Cancer Bone Metastases

    • Martine P. Roudier, Eva Corey, Lawrence D. True, Celestia S. Hiagno, Susan M. Ott, Robert L. Vessella
    Pages 311-339

  15. Back Matter

    Pages 341-344
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Keywords

About this book

Metastasis to bone is a common event in cancer. However, due to the skeleton's unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases.

Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator.

Reviews

"Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications."
(Steven T. Rosen, M.D. Series Editor)

Editors and Affiliations

  • University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, USA

    Evan T. Keller

  • Emory University School of Medicine, Emory University, Atlanta, USA

    Leland W. K. Chung

Bibliographic Information

  • Book Title: The Biology of Skeletal Metastases

  • Editors: Evan T. Keller, Leland W. K. Chung

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4419-9129-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2004

  • Hardcover ISBN: 978-1-4020-7749-4Published: 29 February 2004

  • Softcover ISBN: 978-1-4613-4803-0Published: 12 October 2012

  • eBook ISBN: 978-1-4419-9129-4Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XXI, 344

  • Topics: Cancer Research, Oncology

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