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Lab-on-Chips for Cellomics

Micro and Nanotechnologies for Life Science

  • Book
  • © 2004

Overview

Editors:
  1. Helene Andersson

    1. Royal Institute of Technology, Sweden

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    You can also search for this editor in PubMed   Google Scholar

  2. Albert van den Berg

    1. University of Twente, BIOS, Netherlands

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    You can also search for this editor in PubMed   Google Scholar

  • Provides readers with a quick introduction to the field as well as with a variety of specific examples of such Lab-on-Chip systems for cellomics applications

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv
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  2. Microfluidic devices for cellomics

    • Helene Andersson, Albert van den Berg
    Pages 1-22

  3. Pretreatment of biological sample for microchip analysis

    • Jerome P. Ferrance, James P. Landers
    Pages 23-57

  4. Liposomes as model cellular systems

    • Laurie E. Locascio, Wyatt N. Vreeland, Andreas Jahn, Michael Gaitan
    Pages 59-81

  5. Versatile chip-based tool for the controlled manipulation of microparticles in biology using high Frequency Electromagnetic Fields

    • C. Duschl, P. Geggier, M. Jäger, M. Stelzle, T. Müller, T. Schnelle et al.
    Pages 83-122

  6. Micro-electroporation in cellomics

    • Boris Rubinsky
    Pages 123-141

  7. Patch-Clamp Microsystems

    • T. Lehnert, M. A. M. Gijs
    Pages 143-169

  8. Using lab-on-a-chip Technologies to Understand Cellular Mechanotransduction

    • Dana M. Pirone, Christopher S. Chen
    Pages 171-196

  9. Analysis of Apoptosis on Chip

    • Floor Wolbers, Helene Andersson, Albert van den Berg, Clemens Haanen, Istvan Vermes
    Pages 197-224

  10. On-chip single-cell cultivation systems

    • Kenji Yasuda
    Pages 225-256

  11. Human Embryonic Stem Cells and Microfluidics

    • Vinay V. Abhyankar, David J. Beebe
    Pages 257-272

  12. Cellular and Subcellular Analysis on Chip

    • Hang Lu, Klavs F. Jensen
    Pages 273-298

  13. Microfluidic Cell-Culture Devices

    • Yasuyuki Sakai, Eric Leclerc, Teruo Fujii
    Pages 299-318

  14. Micromachined Bioreactor for in Vitro Cell Self-Assembly and 3D Tissue Formation

    • Karel Domansky, Anand Sivaraman, Linda G. Griffith
    Pages 319-346

  15. Back Matter

    Pages 347-363
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Keywords

About this book

Dear reader, In the past few years we have observed an interesting mutual interest of two fields of research and development in each other. Life sciences area researchers discovered the opportunities offered my micro- and nanotechnology, while people from the microfluidics and BIOMEMS area discovered the application potential of these technologies in cell biology. Unfortunately, these two research communities share little in common: they read and publish in different scientific journals, have incompatible jargons, attend separate conferences, and have a different scientific approach and culture. This is most strikingly illustrated when you give a MEMS researcher some cells to experiment with, or hand over a couple of chips to a cell biologist. Or imagine explaining a microengineer different intracellular apoptotic pathway or a cell biologist about tensile stress in underetched LPCVD membranes. And yet, there is an enormous potential of combining the expertises available in these two fields. It is our goal to illustrate this potential with this book focusing on microfluidics technologies for “cellomics”, research on or with cells. In our view, the field is still too immature to compile a textbook for students, and this volume is rather meant to be a collection of first class papers of leaders in this emerging field. This volume will enable researchers from both communities to get a rapid “state of the art” overview, and also to get an impression what kind of possibilities this area offers. Micro- and nanotechnologists will get inspiration about applications, life science researchers about technological capabilities.

Reviews

From the reviews:

"This is a very timely book on many of the applications of microfluidic chips for cell related experiments. On 360 pages, a series of world renown authors in the 'lab on chip' area disclose some of their most exciting work, give us their opinion and overview of the most rapidly growing application of microfluidics.

The contents is organized in chapters for microfluidic devoices, pretreatment of cell samples, liposome model systems, electric field cell manipulation, electroporation, patch clamp, mechanical measurements on cells, apoptosis, cell cultivation, embryonic stem cell work, single cell experiments, organelle analysis and tissue formation. The book is easy reading for both, engineers and (probably) biologists, with many b/w graphs and photos. There are even a few color plates at the end of the book. Each chapter comes with up-to-date references taken from the scientific literature.

Even though I do not subscribe to terms like 'cellomics' or 'lab on chips,' which I believe are of no scientific value, I actually like the book! The many different authors guarantee a maximum in detail knowledge and expertise, however, the book represents rather a collection of short stories than a comprehensive overview. I also wonder if any biologists were consulted in the process. I suspect the majority of authors are from the engineering sector. I would appreciate a chapter or two on basic microfab, scaling laws related to cell biology and fundamentals of cell biology methods.

Overall, I can recommend this book to any researcher in the 'lab on chip' area, and to curious engineers and scientists in the fields of biology, medicine, chemistry and physics." (Andreas Manz, London, February 6, 2005)

Editors and Affiliations

  • Royal Institute of Technology, Sweden

    Helene Andersson

  • University of Twente, BIOS, Netherlands

    Albert van den Berg

Bibliographic Information

  • Book Title: Lab-on-Chips for Cellomics

  • Book Subtitle: Micro and Nanotechnologies for Life Science

  • Editors: Helene Andersson, Albert van den Berg

  • DOI: https://doi.org/10.1007/978-1-4020-2975-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media B.V. 2004

  • Hardcover ISBN: 978-1-4020-2860-1Published: 06 October 2004

  • Softcover ISBN: 978-1-4020-6562-0Published: 24 September 2007

  • eBook ISBN: 978-1-4020-2975-2Published: 07 September 2007

  • Edition Number: 1

  • Number of Pages: XVI, 364

  • Topics: Biomedicine general, Analytical Chemistry, Biotechnology, Cell Biology, Electronics and Microelectronics, Instrumentation

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