Editors:
- First book to deal with this emerging group of proteases
- Comprehensive review of the current state of research on I-CLiPs
- Contributions by authors recognised as leaders in their fields
- Easy to read descriptive text
Part of the book series: Proteases in Biology and Disease (PBAD, volume 6)
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Table of contents (7 chapters)
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Front Matter
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Back Matter
About this book
In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
Editors and Affiliations
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University of Leeds, Leeds, United Kingdom
Nigel M. Hooper
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Otto-von-Guericke Universität, Magdeburg, Germany
Uwe Lendeckel
Bibliographic Information
Book Title: Intramembrane-Cleaving Proteases (I-CLiPs)
Editors: Nigel M. Hooper, Uwe Lendeckel
Series Title: Proteases in Biology and Disease
DOI: https://doi.org/10.1007/978-1-4020-6311-4
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2007
Hardcover ISBN: 978-1-4020-6310-7Published: 26 July 2007
Softcover ISBN: 978-90-481-7604-5Published: 11 November 2010
eBook ISBN: 978-1-4020-6311-4Published: 21 June 2007
Edition Number: 1
Number of Pages: IX, 142
Topics: Pathology, Neurosciences, Cell Biology