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Peptide Synthesis

Methods and Protocols

  • Book
  • © 2020

Overview

Editors:
  1. Waleed M. Hussein

    1. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia

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  2. Mariusz Skwarczynski

    1. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia

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    You can also search for this editor in PubMed   Google Scholar

  3. Istvan Toth

    1. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2103)

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Solution Phase Peptide Synthesis: The Case of Biphalin

    • Dagmara Tymecka, Aleksandra Misicka
    Pages 1-11

  3. Application of Fmoc-SPPS, Thiol-Maleimide Conjugation, and Copper(I)-Catalyzed Alkyne-Azide Cycloaddition “Click” Reaction in the Synthesis of a Complex Peptide-Based Vaccine Candidate Against Group A Streptococcus

    • Chuankai Dai, Rachel J. Stephenson, Mariusz Skwarczynski, Istvan Toth
    Pages 13-27

  4. In Situ Neutralization Protocols for Boc-SPPS

    • Ramkrishna Adhikary, Philip E. Dawson
    Pages 29-40

  5. Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

    • Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
    Pages 41-57

  6. Automated Solid-Phase Peptide Synthesis

    • Dirk F. H. Winkler
    Pages 59-94

  7. New Developments in Microwave–Assisted Solid Phase Peptide Synthesis

    • Sandeep K. Singh, Jonathan M. Collins
    Pages 95-109

  8. Protecting Groups in Peptide Synthesis

    • Martin Conda-Sheridan, Maddeboina Krishnaiah
    Pages 111-128

  9. Synthesis of O-Acyl Isopeptides: Stepwise and Convergent Solid-Phase Synthesis

    • Taku Yoshiya
    Pages 129-138

  10. An Isodipeptide Building Block for Microwave-Assisted Solid-Phase Synthesis of Difficult Sequence-Containing Peptides

    • Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth
    Pages 139-150

  11. SPOT Synthesis: The Solid-Phase Peptide Synthesis on Planar Surfaces

    • Dirk F. H. Winkler
    Pages 151-173

  12. Solid-Phase Synthesis of Wollamide Cyclohexapeptide Analogs

    • Allan M. Prior, Dianqing Sun
    Pages 175-187

  13. Synthesis of Branched Peptides via a Side-Chain Benzyl Ester

    • Junjie Liu, Jian Li, Xiaobo Tian, Feng Tang, Wei Huang
    Pages 189-198

  14. Solid-Phase Synthesis of Octapeptin Lipopeptides

    • Karl A. Hansford, Zyta M. Ziora, Matthew A. Cooper, Mark A. T. Blaskovich
    Pages 199-213

  15. Peptidomimetic Synthesis: Drug Discovery for Alzheimer’s Disease

    • Yoshio Hamada, Zyta M. Ziora
    Pages 215-223

  16. Synthesis of Amide Backbone-Modified Peptides

    • Abu-Baker M. Abdel-Aal, Richard Raz, George Papageorgiou, John Offer
    Pages 225-237

  17. Synthesis of NickFects, a New Family of CPPs, by Solid-Phase Peptide Synthesis

    • Piret Arukuusk, Ülo Langel
    Pages 239-247

  18. Chemoenzymatic Synthesis of HIV-1 Glycopeptide Antigens

    • Guanghui Zong, Chao Li, Lai-Xi Wang
    Pages 249-262

  19. Synthesis of Antimicrobial Lipopeptides Using the “CLipPA” Thiol-Ene Reaction

    • Yann O. Hermant, Alan J. Cameron, Paul W. R. Harris, Margaret A. Brimble
    Pages 263-274

  20. Decarboxylative Couplings for Late-Stage Peptide Modifications

    • Meng Yao Zhang, Lara R. Malins
    Pages 275-285
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Keywords

About this book

This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Peptide Synthesis: Methods and Protocols serves as an essential guide to the many crucial processes that will allow researchers to efficiently prepare, purify, characterize, and use peptides for chemical, biochemical, and biological studies.

Editors and Affiliations

  • School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia

    Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth

Bibliographic Information

  • Book Title: Peptide Synthesis

  • Book Subtitle: Methods and Protocols

  • Editors: Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-0227-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2020

  • Hardcover ISBN: 978-1-0716-0226-3Published: 27 December 2019

  • Softcover ISBN: 978-1-0716-0229-4Published: 27 December 2020

  • eBook ISBN: 978-1-0716-0227-0Published: 26 December 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XI, 338

  • Number of Illustrations: 79 b/w illustrations, 56 illustrations in colour

  • Topics: Nucleic Acid Chemistry, Pharmaceutical Sciences/Technology

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