Helicobacter pylori

1. Front Matter

   Pages i-xxii

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2. Helicobacter pylori — The organism

   1. Front Matter

      Pages 1-1

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   2. What are the biochemical and physiological implications of the new genetic information?

      • S. L. Hazell, M. A. Trend, G. L. Mendz

      Pages 3-14

   3. The urease system of Helicobacter pylori

      • D. L. Weeks, D. R. Scott, P. Voland, E. A. Marcus, C. Athmann, K. Melchers et al.

      Pages 15-24

   4. The amphibiotic relationship of Helicobacter pylori and humans

      • M. J. Blaser

      Pages 25-30

   5. Helicobacter pylori is pathogenic flora

      • A. Lee

      Pages 31-35

   6. Disease-specific Helicobacter pylori virulence factors: the role of cagA, vacA, iceA, babA2 alone or in combination

      • Y. Yamaoka, D. Y. Graham

      Pages 37-42

3. Helicobacter pylori — Epidemiology

   1. Front Matter

      Pages 43-43

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   2. Factors associated with disappearance of Helicobacter pylori in the West

      • J. Parsonnet

      Pages 45-51

   3. Factors associated with disappearance of Helicobacter pylori in the Far East

      • J. J. Y. Sung

      Pages 53-56

   4. Differences in prevalence of Helicobacter pylori and disease outcomes according to race/environmental factors in Southeast Asia

      • K. L. Goh

      Pages 57-70

4. Novel Helicobacters

   1. Front Matter

      Pages 71-71

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   2. Infection with Helicobacter heilmannii (formerly Gastrospirillum horminis): characterization, epidemiology and therapy

      • P. Malfertheiner, U. R. M. Bohr, T. Günther

      Pages 73-81

   3. Novel Helicobacter species in the intestine

      • A. Lee

      Pages 105-112

5. Novel Helicobacters

   1. Hepatobiliary Helicobacters: recognized animal pathogens with suspected pathogenic potential in humans

      • J. G. Fox

      Pages 83-104

6. Diagnosis of Helicobacter pylori infection

   1. Front Matter

      Pages 113-113

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   2. Diagnosis of Helicobacter pylori infection: faecal antigen determination

      • D. Vaira, C. Ricci, M. Menegatti, C. Acciardi, L. Gatta, A. Geminiani et al.

      Pages 115-122

   3. Pitfalls in Helicobacter pylori diagnosis

      • P. Malfertheiner, A. Leodolter, C. Gerards

      Pages 123-138

7. Inflammation and the Immune Response toHelicobacter pylori Infection

   1. Front Matter

      Pages 139-139

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   2. Overview of immune and inflammatory changes due to Helicobacter infection

      • A. Hamlet, K. Croitoru

      Pages 141-150

The fourth meeting in the very successful series Helicobacter pylori: Basic Mechanisms to Clinical Cure was held on the island of Bermuda in late March 2000. This was only some two years after the third meeting in San Diego and it seemed hardly possible that there would be so much new information. However, as the contributions in this volume testify, there was plenty of exciting new information with important implications for both understanding this infection and for clinical management. Some of this information was of a fundamental nature, such as the role of the acid­ sensitive urel channel in regulating the influx of urea and the formation of ammonia transported back in the microbial periplasmic space to neutralize acid; the observation of genetic polymorphism of the IL-1~ gene as an explanation of achlorhydria and gastric cancer risk in the first-degree relatives of gastric cancer patients; and the peculiar biochemical and physio­ logical consequences of the genome of the microorganisms. The format of the meeting, with short fifteen-minute state-of-the-art pre­ sentations by world experts closely involved in Helicobacter research fol­ lowed by ample time for panel discussions, was again followed this year. Traditional aspects included detailed study of the microbial characteristics, the novel Helicobacters, the interaction with the human host, the peculiarities of the inflammatory immune response, the short and long-term mucosal consequences, the effects on acid secretion, the problem of gastric malignancy and the therapeutic possibilities.

• Gastritis
• antigen
• cancer
• gene
• helicobacter pylori
• infection
• vaccine

`This book provides an extensive compendium of information(with an index) on the recent developments in the broad range of investigations into H.pylori and its varions manifestations. It will be a valuable, up-to-date resource for gastroentelogists, microbiologists, and anyone interested in H.pylori.'
Helicobacter pylori: Basic Mechanisms to Clinical Cure 200 (2000)

• Division of Gastroenterology, McMaster University Medical Centre, Hamilton, Canada

  Richard H. Hunt

• Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands

  Guido N. J. Tytgat

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