Delayed Preconditioning and Adaptive Cardioprotection

1. Front Matter

   Pages i-xvii

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2. Delayed Preconditioning Against Lethal Ischaemic Injury

   • G. F. Baxter, D. M. Yellon

   Pages 1-28

3. Delayed Preconditioning Against Myocardial Stunning: Role of Nitric Oxide as Trigger and Mediator

   • R. Bolli, B. Dawn, X.-L. Tang, Y. Qiu, P. Ping, J. Zhang et al.

   Pages 29-46

4. Delayed Preconditioning Against Endothelial Dysfunction

   • V. Richard, P. Beauchamp, N. Kaeffer, C. Thuillez

   Pages 47-62

5. Delayed Preconditioning Against Ventricular Arrhythmias

   • A. Vegh, J. R. Parratt

   Pages 63-89

6. Intracellular Signalling Mechanisms in Myocardial Adaptation to Ischaemia

   • D. K. Das

   Pages 91-109

7. Changes in Cardiac Gene Expression After Ischaemia and Reperfusion

   • L. V. Mayne

   Pages 111-133

8. The Heat Shock Response and Tissue Protection

   • R. W. Currie, J.-C. L. Plumier

   Pages 135-153

9. Antioxidant Defences in Myocardial Adaptation: Role of Manganese Superoxide Dismutase in Delayed Preconditioning

   • N. Yamashita, T. Kuzuya, M. Hori

   Pages 155-170

10. Endotoxin, Monophosphoryl Lipid A and Delayed Cardioprotection

    • G. J. Gross

    Pages 171-187

11. Adenosine and Delayed Cardioprotection

    • A. Dana, D. M. Yellon, G. F. Baxter

    Pages 189-207

12. Angina and Cardiac Adaptation

    • F. Ottani, M. Galvani, D. Ferrini

    Pages 209-224

13. Back Matter

    Pages 225-230

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Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

• adaptation
• arrhythmia
• endothelium
• heart
• tissue

`This book is recommended for physiologists, cardiologists, and cardiac surgeons vaguely aware of the concept, who want to know more about it.'
Acta cardiologica, 54:3 (1999)
`... this up-to-date review of literature is timely... the editors have done a commendable job of assembling well known experts...to compile this essential review of delayed preconditioning research.'
The Bulletin, 13:2 (2000)

• The Hatter Institute for Cardiovascular Studies, University College London Medical School, London, UK

  G. F. Baxter, D. M. Yellon

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