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Drug Evaluation in Angina Pectoris

  • Book
  • © 1994

Overview

Editors:
  1. Diego Ardissino
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    You can also search for this editor in PubMed   Google Scholar

  2. Lionel H. Opie
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    You can also search for this editor in PubMed   Google Scholar

  3. Stefano Savonitto
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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 158)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Pathophysiology, Clinical Presentation, and Prognosis of Angina Pectoris

    1. Front Matter

      Pages 1-1
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    2. Pathophysiology, Clinical Presentation, and Prognosis of Angina Pectoris

      • Giuseppe Specchia, Stefano Ghio
      Pages 3-11

  3. Evaluation of the Patient with Angina Pectoris

    1. Front Matter

      Pages 13-13
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    2. Clinical Value of Anginal Symptoms and their Assessment in Drug Trials

      • Stefano Savonitto, Piera Angelica Merlini
      Pages 15-30

    3. Quality of Life Assessments in Clinical Trials of Angina Pectoris

      • Ingela Wiklund
      Pages 31-40

    4. Optimizing the Exercise Test for Pharmacological Studies in Patients with Angina Pectoris

      • Jonathan Myers, Victor F. Froelicher
      Pages 41-52

    5. Evaluation of Transient Myocardial Ischemia by Holter Monitoring

      • Arshed A. Quyyumi
      Pages 53-72

    6. Radionuclide Methods for the Evaluation of Ventricular Function and Thrombolytic Therapy

      • Paolo Marzullo, Alessia Gimelli, Antonio L’Abbate
      Pages 73-84

    7. Provocative Testing of Coronary Vasoconstriction

      • Mario Previtali, Paolo Barberis, Diego Ardissino
      Pages 85-101

    8. Pharmacological Investigation Using Invasive Methods

      • Ezio Bramucci, Diego Ardissino
      Pages 103-117

  4. Planning, Conducting, and Evaluating Clinical Trials in Angina Pectoris

    1. Front Matter

      Pages 119-119
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    2. Patient Selection and Definition of Study Endpoints

      • Peter Schulman, David Waters
      Pages 121-127

    3. Controlling Potential Sources of Bias in Clinical Trials of Antianginal Agents

      • Mario Motolese
      Pages 129-138

    4. Parallel-Group and Crossover Designs for Drug Evaluation in the Various Forms of Angina Pectoris

      • Stefano Savonitto
      Pages 139-150

    5. Dose-Response Relationships and Combination Studies with Antianginal Agents

      • Udho Thadani
      Pages 151-156

    6. Sample Size and Power of Clinical Trials

      • Ermanno Eleuteri, Diego Ardissino
      Pages 157-166

    7. Multicenter Trials: Design and Conduct

      • Andrea B. MacNeill, Jacobus Lubsen
      Pages 167-181

  5. Critical Issues Related to Specific Antianginal Agents

    1. Front Matter

      Pages 183-183
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    2. Experimental Evaluation and Clinical Relevance of Tolerance to Nitrates

      • John O. Parker, John D. Parker
      Pages 185-194
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Keywords

About this book

Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris. Drug Evaluation in Angina Pectoris has two fundamental aims: the first is to review the methodological aspects of drug evaluation in stable and unstable angina pectoris; the second is to provide a logical and methodological background for future studies aimed at assessing the ability of medical treatment to improve prognosis.
Part I updates the pathophysiology, clinical presentation and prognosis of angina pectoris. Part II aims to `put in numbers' the symptoms and signs of myocardial ischemia, starting from a revision of the currently used parameters. It is extremely important to quantify the variability of the disease for the correct design of clinical trial, a subject dealt with in Part III, which also discusses some clinico-pharmacological aspects of therapy. Part IV is a critical review of the drugs currently used for the treatment of stable and unstable angina, and particularly considers some important unresolved issues concerning their use. The current FDA and EC guidelines for the evaluation of antianginal drugs are briefly discussed in Part V, giving clinical investigators insight into how antianginal drugs are evaluated by regulatory agencies and what is considered as proof of a valid efficacy/tolerability ratio.
Drug Evaluation in Angina Pectoris will assist discerning cardiologists, pharmacologists, and advanced students of cardiology as well as innovative pharmaceutical companies, all of whom need to understand what angina is, how to evaluate treatment, and how to judge the agents used in its treatment.

Bibliographic Information

  • Book Title: Drug Evaluation in Angina Pectoris

  • Editors: Diego Ardissino, Lionel H. Opie, Stefano Savonitto

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-2628-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1994

  • Hardcover ISBN: 978-0-7923-2897-1Published: 30 November 1994

  • Softcover ISBN: 978-1-4613-6127-5Published: 08 October 2012

  • eBook ISBN: 978-1-4615-2628-5Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XVI, 262

  • Topics: Cardiology

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