Serotonin

1. Front Matter

   Pages i-xii

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2. Molecular and Cell Biology

   1. Different Organization of Human Monoamine Oxidase (Mao) A and B Promoters

      • Jean C. Shih, Qin-Shi Zhu, Joseph Grimsby, Kevin Chen, Jack Shih

      Pages 1-8

   2. Molecular Biology of Serotonin Uptake Sites

      • Beth J. Hoffman

      Pages 9-19

   3. Molecular biology of 5-HT, receptors

      • P. Hartig, N. Adham, J. Bard, A. Hou-yu, H.-T. Kao, M. Macchi et al.

      Pages 21-31

   4. 5-HT1b/D„-Receptor Agonists Block C-Fos-Li Within Trigeminal Nucleus Caudalis in Response to Noxious Meningeal Stimulation

      • Michael A. Moskowitz, Kazuhiko nozaki

      Pages 33-39

3. Pharmacology of Serotonin Receptors

   1. A Reappraisal of 5-HT Receptor Classification

      • P. P. A. Humphrey, P. Hartig, D. Hoyer

      Pages 41-47

   2. Classification of Agents Used in Serotonin Research

      • R. A. Glennon

      Pages 49-54

   3. Electrophysiology of Central Serotonin Neurotransmission

      • P. Blier, G. Piñeyro, T. Dennis, C. De Montigny

      Pages 55-63

   4. Immunohistochemical Visualization of 5-HT1AReceptors in the Rat Brain

      • H. GOZLAN, K. KIA, J. GINGRICH, M. RIAD, E. DOUCET, C. GERARD et al.

      Pages 65-71

   5. In Vitro Functional Correlates Of 5-HT,-Like Receptors

      • D. N. Middlemiss, M. S. Beer, L. O. Wilkinson

      Pages 73-84

   6. 5-HT1DReceptor Subtypes

      • D. Hoyer, A. T. Bruinvels, J. M. Palacios

      Pages 85-97

   7. 5-HT3Receptors

      • GJ. Kilpatrick, H. Rogers

      Pages 99-106

   8. 5-HT4 Receptor: Current Status

      • David E. Clarke, Joel Bockaert

      Pages 107-117

   9. Serotonergic Receptors: from Ligands to Sequence

      • P. A. J. Janssen, H. Moereels

      Pages 119-126

4. Central Cardiovascular Effects and Migraine

   1. Possible Mechanisms of Action of Drugs Effective Against Acute Migraine Attacks

      • Pramod Saxena

      Pages 127-133

   2. SB 203186, A Potent 5-HT4 Antagonist for Cardiac 5-HT4 Receptors

      • Alberto J. Kaumann, Andrew D. Medhurst, Penny Boyland, Mythily Vimal, Rodney C. Young

      Pages 135-139

   3. Role of the Lateral Tegmental Field in the Sympatholytic Action of 5-HT1A Agonists

      • Robert B. Mccall, Mark E. Clement

      Pages 141-149

   4. Urapidil: The Role of 5-HT1A and α-Adrenergic Receptors in Blood Pressure Reduction

      • N. Kolassa, K. D. Beller, R. Boer, H. Boss, K. H. Sanders

      Pages 151-157

5. Prevention of Emesis

   1. Clinical Aspects of Antiemesis: Role of the 5-HT, Antagonists

      • Steven M. Grunberg

      Pages 159-164

   2. The Antiemetic Properties of 5-HT3Receptor Antagonists

      • B. Costall, R. J. Naylor, J. A. Rudd

      Pages 165-170

This volume contains the Proceedings of the invited lectures of the Second International Sym­ posium on SEROTONIN from Cell Biology to Pharmacology and Therapeutics held in Houston, Texas September 15-18, 1992. The meeting was held under the co-sponsorship of the Serotonin Club, the Giovanni Lorenzini Medical Foundation, and the Fondazione Giovanni Lorenzini. This volume discusses the major exploration in knowledge that has occurred recently of the complex role that 5- hydroxytryptamine (serotonin) plays in health and disease. In par­ ticular, these Proceedings highlight major breakthroughs in molecular biology and classification of receptor subtypes that are responsible for the many actions of the monoamine. The ever­ increasing importance of serotonin in central regulation, whether autonomic or behavioral is represented by a large number of chapters prepared by world experts. Additionally, the role of serotonin in peripheral organs is also discussed. Hence, this volume provides the reader with a unique, up-to-date review of this exciting and novel area of science. These Proceedings obviously are of great interest, not only to the researchers directly engaged in the quest for the understanding and unraveling of the actions of the interactions with serotonin as a major neurohumoral mediator, but also to all scholars and clinicians who wish to acquire a better understanding of the functioning of the brain and of peripheral organs. Since this volume was constructed as a compilation of invited lectures, the scientific content and the opinions expressed in the chapters are the sole responsibility of the authors.

• biology
• cell
• cell biology
• depression
• drug
• drug abuse
• memory
• neuroprotection
• receptor
• regulation
• research
• schizophrenia
• serotonin

• Baylor College of Medicine, Houston, USA

  P. M. Vanhoutte

• Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

  P. R. Saxena

• Institute of Pharmacological Sciences, University of Milan, Milan, Italy

  R. Paoletti

• University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

  N. Brunello

• Giovanni Lorenzini Medical Foundation, Houston, USA

  A. S. Jackson

Policies and ethics