Breast Cancer: Biological and Clinical Progress

1. Front Matter

   Pages i-xix

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2. Activation of Cellular Oncogenes

   1. Front Matter

      Pages 1-1

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   2. The Role of Oncogenes and Onco-Suppressor Genes in Human Breast Cancer

      • Demetrios A. Spandidos

      Pages 3-10

   3. Expression of the MET Oncogene in Human Tumors

      • M. F. Di Renzo, M. Prat, M. Olivero, T. Crepaldi, P. M. Comoglio

      Pages 11-21

   4. c-erbB-2, a Tyrosine Kinase Growth Factor Receptor and its Role in Breast Cancer

      • F. J. Lofts, W. J. Gullick

      Pages 23-40

   5. Mammary Morphogenesis and Oncogenes

      • Robert D. Cardiff, David Ornitz, Frederick Lee, Randall Moreadith, Eric Sinn, William Muller et al.

      Pages 41-55

3. Polypeptides and Growth Factors Expression

   1. Front Matter

      Pages 57-57

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   2. Interdependence of Hormones and Growth Factors in Lobulo-Alveolar Development of the Mammary Gland and in Tumorigenesis

      • Barbara K. Vonderhaar, Karen Plaut

      Pages 59-80

   3. The Role of Estrogen Regulated Secreted Proteins for Growth Regulation of Human Breast Cancer

      • Anne E. Lykkesfeldt, Inga Laursen, Per Briand

      Pages 81-91

   4. The Prolactin-Inducible Protein / Gross Cystic Disease Fluid Protein (PIP/GCDFP-15): Genetic Analysis and Hormonal Regulation of Gene Expression

      • R. Shiu, Y. Myal, D. Tsuyuki, D. Robinson, B. Iwasiow, A. Yarmill et al.

      Pages 93-101

4. Mammary Epithelium and Stroma in Vivo and in Vitro

   1. Front Matter

      Pages 103-103

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   2. Role of Ras Oncogene in Human Breast Cancer: An Experimental Approach

      • J. Russo, G. Calaf, J. Ochieng, I. H. Russo, Q. Tahin, P.-L. Zhang

      Pages 105-117

   3. Interactions Between Malignant and Non-Malignant Components of the Breast

      • W. R. Miller

      Pages 119-136

   4. Involvement of Heparanase and Extracellular Matrix-Bound Fibroblast Growth Factor in Tumor Progression

      • I. Vlodavsky, R. Ishai-Michaeli, M. Mohsen, G. Korner, R. Catane

      Pages 137-150

5. Hormone Responsiveness and Oral Contraceptives

   1. Front Matter

      Pages 151-151

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   2. Estrogen and Progesterone Receptor Activity in Breast Cancer Cells

      • Saverio Bettuzzi, Alan Robinson, Robin Fuchs-Young, Geoffrey L. Greene

      Pages 153-167

   3. Oral Contraceptives and Breast Cancer: The Scope for a Hypothesis-Oriented Approach

      • Carlo La Vecchia

      Pages 169-177

6. Risk Factors; Monitoring of Breast Cancer Progression and Regression

   1. Front Matter

      Pages 179-179

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   2. Benign Breast Disease: Links to Risk of Cancer

      • David L. Page, William D. Dupont

      Pages 181-193

   3. Proliferation Rate in Different Cell Types in Benign Breast Disease

      • A. Sapino, L. Macrì, P. Gugliotta, C. Manini, G. Bussolati

      Pages 195-206

The fight against breast cancer is expected to be effectively stimulated by interdisciplinary approaches and cross-fertilization between laboratory and clinical research findings. Of major importance are therefore meetings promoting fast transfer to clinical applications of findings by basic scientists. The present volume, reporting the proceedings of the 1991 Biennial Conference of the International Association for Breast Cancer Research, hopes to achieve this goal by presenting the most recent observations in the laboratory and their possible applications for diagnostic evaluations and clinical treatments. The sections of the book focus first on the oncogenes more likely involved in mammary tumorigenesis and on the polypeptide factors and steroid hormones affecting proliferation and possibly inducing carcinogenesis in breast epithelium. A section is devoted to the epidemiological studies and to the identification of risk factors, a way to select populations at higher risk and, possibly, to help in preventing the disease. Special emphasis is given to the establishment of diagnostic criteria and to the selection of prognostic factors, which must support an effective therapeutic planning. It is our hope that this volume, a timely update of the most recent advances in specific fields presented by basic scientists, pathologists and clinicians will stimulate new insights and progresses leading ultimately to the control of breast cancer.

• cancer treatment
• carcinogenesis
• cell
• hormones
• metastasis
• oncogene
• tumor
• tumor progression
• tumorigenesis

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