Radioiodination: Theory, Practice, and Biomedical Applications

1. Front Matter

   Pages i-1

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2. Introduction

   1. Front Matter

      Pages 3-3

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   2. History of Development of Iodine-Labeled Tracers

      • Mrinal K. Dewanjee

      Pages 5-9

   3. Physical Decay Characteristics of Radioisotopes of Iodine

      • Mrinal K. Dewanjee

      Pages 11-17

   4. Principles of Measurement of Radioiodinated Tracers and Related Instruments

      • Mrinal K. Dewanjee

      Pages 19-25

   5. Radiation Dosimetry of Iodine-Labeled Tracers

      • Mrinal K. Dewanjee

      Pages 27-36

   6. Hazards in the Handling of Radioiodide-Labeled Compounds and Central Facility for Radioiodination

      • Mrinal K. Dewanjee

      Pages 37-46

   7. Production of 131I, 125I, and 123I Radionuclides and their Separation from Targets

      • Mrinal K. Dewanjee

      Pages 47-65

3. Preparation of Tracers

   1. Front Matter

      Pages 67-67

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   2. Chemistry of Radioiodination Reactions

      • Mrinal K. Dewanjee

      Pages 69-125

4. Localization of Tracers

   1. Front Matter

      Pages 127-127

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   2. Methods of Radioiodination Reactions with Several Oxidizing Agents

      • Mrinal K. Dewanjee

      Pages 129-218

   3. Mechanisms of Tracer Localization

      • Mrinal K. Dewanjee

      Pages 219-229

5. Organ Imaging and Tracer Applications

   1. Front Matter

      Pages 231-231

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   2. Radioiodinated Small Molecules and Their Applications

      • Mrinal K. Dewanjee

      Pages 233-387

   3. Radioiodinated Macromolecules

      • Mrinal K. Dewanjee

      Pages 389-411

   4. Applications of Radioiodinated Macromolecules

      • Mrinal K. Dewanjee

      Pages 413-512

   5. Radioiodinated Lipoproteins

      • Mrinal K. Dewanjee

      Pages 513-522

   6. Radioiodinated Peptides and Growth Factors and Their Applications

      • Mrinal K. Dewanjee

      Pages 523-531

   7. Miscellaneous Radioiodinated Polymers and Beads

      • Mrinal K. Dewanjee

      Pages 533-536

Among the readily available -emitting radionuclides, the nuclides of iodine have the greatest versatility in labeling both the hydrophilic and the lipophilic compounds that are used in biology and medicine. Biologically important micrmolecules, semimacromolecules, and macromolecules have been identified which, after iodination, almost maintain the same molecular configuration and similar biologic specificity as those of the parent molecules. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. 125r, with a half-life of 60 days, has a crucial role in competitive protein-binding studies. 131r is useful for measuring thyroid uptake, for the diagnosis of thyroid carcinoma and metastasis, and for therapy. 1nr , with a reasonably shorter half-life, is almost ideal for thyroid workup and for a few useful labeled radiopharmaceutical. Although ~c is used more widely in diagnostic procedures, the radionuclides of iodine will always have a major role in biology and medicine. A considerable amount of information is scattered in the literature regarding the chemistry of radioiodination and the mechanism of tracer localization in cells and tissues. Labeled peptides, proteins, and antibodies are extensively used for protein turnover studies, receptor binding and tumor imaging studies, and radioimmunoassay. The general trend in the use of tracers in clinical nuclear medicine has been an evolution from 3H, 14C, 11C, and 13 to 125 , 131 and 123r to ~c and 111rn.

• dosimetry
• imaging
• nuclear medicine
• pharmacology
• radiation
• radiation damage
• Diagnostic Radiology

• Radiopharmaceutical Laboratory, USA

  Mrinal K. Dewanjee

• Jackson Memorial Medical Center and University of Miami Hospital and Clinics, USA

  Mrinal K. Dewanjee

• Surgery and Biomedical Engineering, University of Miami School of Medicine, USA

  Mrinal K. Dewanjee

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