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Transplantation of Composite Tissue Allografts

  • Book
  • © 2008

Overview

Editors:
  1. Charles W. Hewitt

    1. Division of Surgical Research UMDNJ-Robert Wood Johnson Medicine Medical School, Cooper University Hospital, Camden

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  2. W. P. Andrew Lee

    1. Division of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

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  3. Chad R. Gordon

    1. Department of Surgery UMDNJ-Robert Wood Johnson Medical School, Cooper University Hospital, Camden

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  • Represents the most up-to-date research on a new and emerging field of biomedical research that has exploded in recent years

  • The clinical application of the first successful hand transplant in the U.S. was in 1999 and is discussed in this volume; any book published prior to this book will be lacking a large part of this scientific milestone

  • Includes supplementary material: sn.pub/extras

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-xx
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  2. Section I

    1. The Establishment of Composite Tissue Allotransplantion as a Clinical Reality

      • Joseph E. Murray
      Pages 3-12

    2. The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of “Cosmas and Damian”

      • Chad R. Gordon, Joseph M. Serletti, Kirby S. Black, Charles W. Hewitt
      Pages 13-25

    3. The Impact of the Discovery of Cyclosporine on Transplantation of Composite Tissue Allografts

      • Zsolt T. Csapo, Bence Forgacs, Barry D. Kahan
      Pages 26-35

    4. The First Limb Transplants with Cyclosporine

      • Christopher J. Salgado, Samir Mardini, Charles W. Hewitt
      Pages 36-39

  3. Section II

    1. Translational Research in Composite Tissue Allotransplantation

      • Linda C. Cendales, David E. Kleiner, Allan D. Kirk
      Pages 43-54

    2. Relative Antigenicity of Allograft Components and Differential Rejection

      • Jignesh Unadkat, Justin M. Sacks, Stefan Schneeberger, W. P. Andrew Lee
      Pages 55-69

    3. On the Road to Tolerance Induction in Composite Tissue Allotransplantation

      • Mark A. Hardy
      Pages 70-87

    4. Donor-Specific Tolerance

      • Au H. Bui, Gerald Lipshutz, Jerzy Kupiec-Weglinski
      Pages 89-104

    5. Immune Tolerance Induction: Basic Concepts for Composite Tissue Allotransplantation

      • Patricio Andrades, Clement Asiedu, Judith M. Thomas
      Pages 105-117

  4. Section III

    1. Allograft Survival with Calcineurin Inhibitors

      • Neil F. Jones, Esther Voegelin
      Pages 121-149

    2. Long-Term Prevention of Rejection and Combination Drug Therapy

      • Thomas H. Tung
      Pages 150-162

    3. Locoregional Immunosuppression in Composite Tissue Allografting

      • Scott A. Gruber
      Pages 164-171

    4. New Approaches to Antibody Therapy

      • Dalibor Vasilic, Moshe Kon, Cedric G. Francois
      Pages 172-190

  5. Section IV

    1. World Experience of Hand Transplantation-Independent Assessment

      • W. P. Andrew Lee, Justin M. Sacks, Cedric Elaine K. Horibe
      Pages 193-208

    2. Hand Transplantation: Lyon Experience

      • Palmina Petruzzo, Emmanuel Morelon, Jean Kanitakis, Lionel Badet, Assia Eljaafari, Marco Lanzetta et al.
      Pages 209-214

    3. Hand Transplantation: The Louisville Experience

      • Vijay S. Gorantla, Warren C. Breidenbach III
      Pages 215-233

    4. Hand Transplantation: The Innsbruck Experience

      • Stefan Schneeberger, Marina Ninkovic, Raimund Margreiter
      Pages 234-250

  6. Section V

    1. Vascularized Bone Marrow Transplantation

      • Chau Y. Tai, Louise F. Strande, Hidetoshi Suzuki, Martha S. Matthews, Chad R. Gordon, Charles W. Hewitt
      Pages 253-271

    2. Vascularized Bone Marrow Transplantation: Pathology of Composite Tissue Transplantation-Induced Graft-Versus-Host-Disease

      • Rajen Ramsamooj, Charles W. Hewitt
      Pages 272-277
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Keywords

About this book

This book reviews, updates, and synthesizes the recent accomplishments and on- ing research in the field of composite tissue allotransplantation (CTA). The volume focuses on the immunology, biotechnology, and bioengineering of CTA, as these areas have demonstrated the most growth within the field in the last five years. The text presents the entire scope of CTA in a comprehensive format. This effort details the state-of-art advances of CTA and includes the numerous accompli- ments of premier scientists and physicians from around the world engaged in the field. Significant advancements in the evolution of CTA are detailed from the h- toric legend of “Cosmas and Damian” through the most recent controversial topics of hand and face transplantation. Transplantation of Composite Tissue Allografts is an ideal and valuable resource for a diverse group of physicians, scientists, researchers, residents, and students. This book will both inform and excite all who are interested in helping patients benefit from transplantation of composite tissue allografts.

Reviews

PRINTED IN THE JULY 2008 ISSUE OF ANNALS OF PLASTIC SURGERY



Hewitt CW, Lee WPA, Gordon CR, eds. Transplantation of Composite Tissue Allografts. New York: Springer; 2008, 498 pp, $169.00.

 

 

Some books are indispensable to their times. Forty years ago, plastic surgeons were redefining many surgical problems and much of their surgical thinking into more rigorous biologic concepts of wound healing. Peacock and Van Winkle published their Surgery and Biology of Wound Repair in 1970,1<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi#19> and provided the fundamental text for that evolutionary period.

I believe that Transplantation of Composite Tissue Allografts is, likewise, an indispensable book for the developing era of reconstructive transplantation. This field should broadly engage reconstructive plastic surgeons. While organ transplantation, though clinically pioneered by Nobel-laureate plastic surgeon Joseph Murray, could readily move into the realm of general surgery technique, composite transplantation of limbs and facial units will necessarily demand the skills of microsurgery, peripheral nerve surgery, and reconstructive surgery provided by plastic surgeons. Plastic surgeons who hope to participate in these developments (or even intelligently follow them) should read this book.

The book is a multiauthored text, but it is a competently organized one, with good coordination of contributions and minimal redundancy. Current biologic concepts and clinical application of composite tissue transplantation are presented with detail and intelligent interpretation.

The section on immunosuppression and tolerance are excellent summaries of these experimental concepts and current clinical applications. The persistent hazards of immunosuppression and the elusiveness of induced tolerance are honestly summarized. Thorough descriptions of immunosuppressive agents and immunologic strategies are valuable parts of these sections.

The clinical summaries of composite tissue transplants to date illustrate the potentials and problems of these procedures. I began reading this volume with the opinion that single hand transplants have been a bad idea so far, with questionable functional outcomes, immunosuppression complications, rejection episodes that could lead to chronic rejection syndromes, and out-right failure associated problems of patient selection and support.2<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi#20> Reading this book did not change my mind. This reading, however, further impressed me with the utility of the bilateral hand transplant procedures. Careful analysis of transplantation cases as presented in this book will be the invaluable basis for judging clinical results and projecting applications in the future of reconstructive transplantation.

I congratulate the editors and authors on the timely and well-executed volume. I recommend it highly.

William C. Lineaweaver, MD

Editor

REFERENCES[http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/gifs/ftup.gif]<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi#toc>

1. Peacock E, Van Winkle W. Surgery and biology of wound repair. Philadelphia: Saunders; 1970. [Context Link]<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi#10>

2. Lineaweaver W. Chronic rejection, hand transplantation, and the monkey's paw (editorial). Microsurgery. 2006;26:419. Bibliographic Links<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi?Link+Set+Ref=00000637-200807000-00023|00005783_2006_26_419_lineaweaver_transplantation_%7c00000637-200807000-00023%23xpointer%28id%28R2-23%29%29%7c60%7chttp%3a%2f%2facs.tx.ovid.com%2facs%2f.14038a58de48ffa86f4ee5c84b99ffb3634b4b40918581081964493cf03a9948ecbddf0655fc0acf8b.gif%7covftdb%7c&P=20&S=EICEFPDDJEDDJIEDNCHLDDMJDAPPAA00&WebLinkReturn=Full+Text%3dL%7cS.sh.15.16.18.40%7c0%7c00000637-200807000-00023> [Context Link]<http://ovidsp.tx.ovid.com.libproxy2.umdnj.edu/spb/ovidweb.cgi#14>

Editors and Affiliations

  • Division of Surgical Research UMDNJ-Robert Wood Johnson Medicine Medical School, Cooper University Hospital, Camden

    Charles W. Hewitt

  • Division of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

    W. P. Andrew Lee

  • Department of Surgery UMDNJ-Robert Wood Johnson Medical School, Cooper University Hospital, Camden

    Chad R. Gordon

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