Cortical Deficits in Schizophrenia

1. Front Matter

   Pages i-xiii

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2. Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms

   • Paul J. Harrison

   Pages 1-16

3. Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function

   • Anil K. Malhotra, Pamela DeRosse, Katherine E. Burdick

   Pages 17-28

4. Homer: A Genetic Factor in Schizophrenia?

   • Karen K. Szumlinski, Todd E. Kippin

   Pages 29-72

5. Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia

   • Christine Roy, Gabriel Corfas

   Pages 73-96

6. Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia

   • Jason R. Tregellas, Robert Freedman

   Pages 97-111

7. A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia

   • Deborah Bauer, Robert E. McCullumsmith, James H. Meador-Woodruff

   Pages 113-147

8. Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia

   • Robert Greene

   Pages 149-155

9. Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications

   • Subroto Ghose, Carol A. Tamminga

   Pages 157-190

10. Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses

    • Francine M. Benes, Benjamin Lim, David Matzilevich, John Walsh

    Pages 191-203

11. Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences

    • David A. Lewis, Takanori Hashimoto, Jaime G. Maldonado-Aviles, Harvey Morris

    Pages 205-218

12. Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology

    • Patricio O'Donnell

    Pages 219-236

13. Back Matter

    Pages 237-239

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The genetics of schizophrenia have taken the driver seat in the research - lated to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide pat- physiological scenarios that could link those cellular phenomena with sy- toms. In this book, we have chosen to elaborate on that link. The contributions to this book have been requested to reflect the current state of the connection between schizophrenia genetics and pathophysiology. The book opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes.

• DNA
• Motivation
• attention
• behavior
• genes
• genetics
• physiology
• schizophrenia

From the reviews:

"Cortical Deficits in Schizophrenia: From Genes to Function is an important contribution to the literature on schizophrenic syndrome analysis. It also can serve as an excellent model of productive interdisciplinary collaboration. Clinical as well as basic scientific specialists from a very wide variety of disciplines who share a common interest in schizophrenic syndrome analysis will find much new information in this work that is insightful, original, and exceptionally well integrated." (James A. Moses, PsycCRITIQUES, Vol. 34 (3), August, 2008)

• University of Maryland School of Medicine, Baltimore, USA

  Patricio O'Donnell

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