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  • Book
  • © 2006

Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules

  • Distinguished list of authors, many of whom are among the leaders or founders in the field
  • Broader overview of the field than existing literature
  • Bridges the gap from the bench to the bedside
  • Includes supplementary material: sn.pub/extras

Part of the book series: Medical Intelligence Unit (MIUN)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xviii
  2. Research Applications

    1. Front Matter

      Pages 1-1
    2. The Many Faces of PNA

      • Peter E. Nielsen
      Pages 3-17
    3. Modulation of Nucleic Acid Information Processing by PNAs

      • Lionel Bastide, Bernard Lebleu, Ian Robbins
      Pages 18-29
    4. Targeted Gene Delivery

      • Kenneth W. Liang, Feng Liu, Leaf Huang
      Pages 30-37
    5. Morpholinos and PNAs Compared

      • James E. Summerton
      Pages 89-113
    6. Chemistry of Locked Nucleic Acids (LNA)

      • Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch
      Pages 114-132
  3. Clinical Applications

    1. Front Matter

      Pages 149-149
    2. Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology

      • Nadia Zaffaroni, Raffaella Villa, Marco Folini
      Pages 171-180
    3. PNAs as Novel Cancer Therapeutics

      • Luca Mologni, Carlo Gambacorti-Passerini
      Pages 181-194
    4. Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids

      • Olivier Zelphati, Jiin Felgner, Yan Wang, Xiaowu Liang, Xiaodong Wang, Philip Felgner
      Pages 195-211
    5. Locked Nucleic Acids (LNA) and Medical Applications

      • Henrik Ørum, Andreas Wolter, Lars Kongsbak
      Pages 212-222
    6. Peptide Nucleic Acids

      • David R. Corey
      Pages 236-242
    7. The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy

      • Paul M. Smith, Günther F. Ross, Theresa M. Wardell, Robert W. Taylor, Douglass M. Turnbull, Robert N. Lightowlers
      Pages 243-251
    8. Gene Silencing through RNA Interference

      • David O. Azorsa, Spyro Mousses, Natasha J. Caplen
      Pages 252-264

About this book

This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

Authors and Affiliations

  • Departments of Neurosurgery, Neurology and Molecular Genetics Cell and Gene Therapy Center, UMDNJ-Robert Wood Johnson Medical School, Camden, USA

    Christopher G. Janson

  • Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

    Matthew J. During

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access