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  • © 2002

Intractable Seizures

Diagnosis, Treatment, and Prevention

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 497)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xiv
  2. Intractable Epilepsy in Adults

    1. Intractable Epilepsy in Adults

      • Ilo E. Leppik
      Pages 1-7
  3. Complex Partial Seizures

    1. Complex Partial Seizures

      • Warren T. Blume
      Pages 9-18
    2. Surgery for Complex Partial Seizures

      • John P. Girvin
      Pages 27-32
  4. West’s Syndrome (Infantile Spasms)

    1. West’s Syndrome (Infantile Spasms)

      • Richard A. Hrachovy
      Pages 33-50
    2. Drug Therapy for West’s Syndrome

      • Catherine Chiron, Olivier Dulac
      Pages 51-56
    3. Surgery for West’s Syndrome

      • Harold J. Hoffman
      Pages 57-59
  5. Lennox-Gastaut Syndrome

    1. Lennox-Gastaut Syndrome

      • Ernst Niedermeyer
      Pages 61-75
    2. Drug Therapy in Lennox-Gastaut Syndrome

      • Kevin Farrell
      Pages 77-86
  6. Special Topic

  7. Basic Pathophysiology—Theories and Research

    1. Why are Complex Partial Seizures Intractable?

      • W. McIntyre Burnham
      Pages 107-110
    2. Pathophysiology of Infantile Spasms

      • Harry T. Chugani
      Pages 111-121
    3. Functional Properties of Human Neocortical Neurons

      • Massimo Avoli, Donatella Mattia, Andre Olivier
      Pages 123-132
  8. Effects of Unchecked Seizures—Human and Animal Studies

    1. Psychiatric Aspects of Intractable Epilepsy

      • Dietrich Blumer
      Pages 133-147
    2. Neural Growth, Neural Damage and Neurotrophins in the Kindling Model of Epilepsy

      • Ronald J. Racine, Beth Adams, Philip Osehobo, Margaret Fahnestock
      Pages 149-170
    3. Effects of Uncontrolled Seizures

      • Carl E. Stafstrom, Gregory L. Holmes
      Pages 171-194
  9. New Therapeutic Strategies

    1. The Landau-Kleffner Syndrome

      • Hanna Kolski, Hiroshi Otsubo
      Pages 195-208
    2. Neuroprotective Strategies in Epilepsy

      • Peter L. Carlen, Marc R. Pelletier, Aviv Ouanounou, Michael Tymianski, Liang Zhang
      Pages 209-224

About this book

About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.

Editors and Affiliations

  • University of Toronto, Toronto, Canada

    W. McIntyre Burnham, Paul A. Hwang

  • Toronto Western Research Institute, Toronto, Canada

    Peter L. Carlen

Bibliographic Information

  • Book Title: Intractable Seizures

  • Book Subtitle: Diagnosis, Treatment, and Prevention

  • Editors: W. McIntyre Burnham, Peter L. Carlen, Paul A. Hwang

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1335-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-46621-2Published: 30 April 2002

  • Softcover ISBN: 978-1-4613-5503-8Published: 12 October 2012

  • eBook ISBN: 978-1-4615-1335-3Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 248

  • Topics: Neurology, Neurosciences

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access