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The Functional Roles of Glial Cells in Health and Disease

Dialogue between Glia and Neurons

  • Book
  • © 1999

Overview

Editors:
  1. Rebecca Matsas

    1. Hellenic Pasteur Institute, Athens, Greece

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    You can also search for this editor in PubMed   Google Scholar

  2. Marco Tsacopoulos

    1. University of Geneva Medical School, Geneva, Switzerland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 468)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-x
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  2. Glial Cell Development

    1. Front Matter

      Pages 1-1
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    2. Developmental Regulation in the Schwann Cell Lineage

      • K. R. Jessen, R. Mirsky
      Pages 3-12

    3. Transcriptional Regulation of the Pou Gene Oct-6 in Schwann Cells

      • Wim Mandemakers, Ronald Zwart, Robert Kraay, Gerard Grosveld, Anneke Graus Martine Jaegle, Ludo Broos et al.
      Pages 13-22

    4. Glia Development in the Embryonic Cns of Drosophila

      • Christian Klämbt, Kristina Schimmelpfeng, Thomas Hummel
      Pages 23-32

    5. Role and Mechanism of Action of Glial Cell Deficient/Glial Cell Missing (Glide/Gcm), The Fly Glial Promoting Factor

      • A. A. Miller, R. Bernardoni, C. Hindelang, M. Kammerer, S. Sorrentino, V. Van de Bor et al.
      Pages 33-46

  3. Glia In Neurotransmission, Neuromodulation, and Neuron Survival

    1. Front Matter

      Pages 47-47
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    2. Expression and Functional Analysis of Glutamate Receptors in Glial Cells

      • Daniele F. Condorelli, Fiorenzo Conti, Vittorio Gallo, Frank Kirchhoff, Gerald Seifert, Christian Steinhäuser et al.
      Pages 49-67

    3. Astrocytes as Active Participants of Glutamatergic Function and Regulators of its Homeostasis

      • Paola Bezzi, Sabino Vesce, Patrizia Panzarasa, Andrea Volterra
      Pages 69-80

    4. Glia-Neuron Interaction by High-Affinity Glutamate Transporters in Neurotransmission

      • Thomas Rauen, Frauke Fischer, Michael Wiessner
      Pages 81-95

    5. On How Altered Glutamate Homeostasis May Contribute to Demyelinating Diseases of the Cns

      • Carlos Matute, María Domercq, David J. Fogarty, María Pascual de Zulueta, María Victoria Sánchez-Gómez
      Pages 98-107

    6. Possible Role of Microglial Prostanoids and Free Radicals in Neuroprotection and Neurodegeneration

      • Luisa Minghetti, Elisabetta Polazzi, Alessia Nicolini, Anita Greco, Giulio Levi
      Pages 109-119

  4. Glia, Inflammation, and Cytokines

    1. Front Matter

      Pages 121-121
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    2. The Role of Microglia and Astrocytes in Cns Immune Surveillance and Immunopathology

      • Francesca Aloisi
      Pages 123-133

    3. The Role of Chemokines in the Pathogenesis of Multiple Sclerosis

      • N. Woodroofe, A. K. Cross, K. Harkness, J. E. Simpson
      Pages 135-150

    4. Humoral and Cellular Immune Functions of Cytokine-Treated Schwann Cells

      • Gisela Wohlleben, Hans-Peter Hartung, Ralf Gold
      Pages 151-156

    5. Axotomy-Induced Glial Reactions in Normal and Cytokine Transgenic Mice

      • B. Finsen, N. D. Lomholt, I. V. Hegelund, F. R. Poulsen, M. B. Jensen, T. Owens
      Pages 157-171

  5. Glia in cns Plasticity and Regeneration

    1. Front Matter

      Pages 173-173
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    2. Contribution of Astrocytes to Activity-Dependent Structural Plasticity in the Adult Brain

      • Dionysia T. Theodosis, Dominique A. Poulain
      Pages 175-182

    3. The Role of Oligodendrocytes and Oligodendrocyte Progenitors in cns Remyelination

      • Hans S. Keirstead, William F. Blakemore
      Pages 183-197
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Keywords

About this book

Thirty-five years ago, when Stephen Kuffler and his colleagues at Harvard initiated a new era of research on the properties and functions of neuroglial cells, very few neuro­ scientists were impressed at the time with the hypothesis that neuroglial cells could have another, though more subtle, role to play in the nervous system than to provide static support to neurons. Today, very few neuroscientists are unaware of the fact that multiple interactions between neurons and glial cells have been described, and that they consti­ tute the basis for understanding the function and the pathology of the nervous system. Glial cells outnumber neurons and make up about one-half of the bulk of the nervous system. They are divided into two major classes: first, the macroglia, which include astrocytes and oligodendrocytes in the central nervous system, and the Schwann cells in the peripheral nervous system; and second, the microglial cells. These different classes of glial cells have different functions and contribute in different ways in the devel­ opment, function, and the pathology of the nervous system.

Editors and Affiliations

  • Hellenic Pasteur Institute, Athens, Greece

    Rebecca Matsas

  • University of Geneva Medical School, Geneva, Switzerland

    Marco Tsacopoulos

Bibliographic Information

  • Book Title: The Functional Roles of Glial Cells in Health and Disease

  • Book Subtitle: Dialogue between Glia and Neurons

  • Editors: Rebecca Matsas, Marco Tsacopoulos

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-4685-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1999

  • Hardcover ISBN: 978-0-306-46205-4Published: 31 October 1999

  • Softcover ISBN: 978-1-4613-7121-2Published: 30 October 2012

  • eBook ISBN: 978-1-4615-4685-6Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 389

  • Topics: Neurosciences, Neurology

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