Co-signal Molecules in T Cell Activation

1. Front Matter

   Pages i-vi

   PDF

2. Basic Understanding of Co-signal Molecules in T Cell Activation

   1. Front Matter

      Pages 1-1

      PDF

   2. Co-signal Molecules in T-Cell Activation

      • Miyuki Azuma

      Pages 3-23

   3. The CD28–B7 Family of Co-signaling Molecules

      • Shigenori Nagai, Miyuki Azuma

      Pages 25-51

   4. The TNF–TNFR Family of Co-signal Molecules

      • Takanori So, Naoto Ishii

      Pages 53-84

   5. Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors

      • Shuhei Ogawa, Ryo Abe

      Pages 85-133

   6. Molecular Dynamics of Co-signal Molecules in T-Cell Activation

      • Takashi Saito

      Pages 135-152

   7. Role of Co-stimulatory Molecules in T Helper Cell Differentiation

      • Michelle Schorer, Vijay K. Kuchroo, Nicole Joller

      Pages 153-177

   8. Control of Regulatory T Cells by Co-signal Molecules

      • James Badger Wing, Christopher Tay, Shimon Sakaguchi

      Pages 179-210

3. Co-signal Molecules in Health and Disease

   1. Front Matter

      Pages 211-211

      PDF

   2. Stimulatory and Inhibitory Co-signals in Autoimmunity

      • Taku Okazaki, Il-mi Okazaki

      Pages 213-232

   3. Co-signaling Molecules in Neurological Diseases

      • Pia Kivisäkk, Samia J. Khoury

      Pages 233-265

   4. Costimulation Blockade in Transplantation

      • Melissa Y. Yeung, Tanja Grimmig, Mohamed H. Sayegh

      Pages 267-312

   5. Cancer Immunotherapy Targeting Co-signal Molecules

      • Masao Nakajima, Koji Tamada

      Pages 313-326

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated.Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.   

• Costimulation
• Coinhibition
• Immune Regulation
• CD28
• TNF-TNFR
• T lymphocytes
• Cancer Immunotherapy

     

• Department of Molecular Immunology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

  Miyuki Azuma

• Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

  Hideo Yagita

Miyuki Azuma
Tokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan


Hideo Yagita
Juntendo University School of Medicine, Dept of Immunology, Japan  

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