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Cancer Cell Metabolism: A Potential Target for Cancer Therapy

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  • © 2020

Overview

Editors:
  1. Dhruv Kumar

    1. Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, India

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  • Reveals the molecular mechanism of metabolic regulation in cancer cells

  • Provides comprehensive, up-to-date information on different types of metabolic alteration in cancer cells with comparison to normal cells

  • Offers an authoritative account of the latest findings on all clinically approved and prospective anti-cancer drugs targeting the metabolic process and associated signalling pathways in the cancer cells

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Cancer Cell Metabolism: Solid Tumor Versus Nonsolid Tumor

    • Sibi Raj, Vaishali Chandel, Dhruv Kumar
    Pages 1-13

  3. Reprogramming of Cancer Cell Metabolism: Warburg and Reverse Warburg Hypothesis

    • Samyukta Narayanan, Anirudh Santhoshkumar, Srijit Ray, Sitaram Harihar
    Pages 15-26

  4. Molecular Aspects of Cancer Cell Metabolism: Altered Glycolysis and Lipid Metabolism

    • Sandesh Kumar Patel, Deepanshu Verma, Neha Garg
    Pages 27-37

  5. Understanding the Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts

    • Anthony Michael Alvarado, Levi Kent Arnold, Sufi Mary Thomas
    Pages 39-53

  6. Metabolic Cross Talk Between Cancer Cells and Tumor Microenvironment

    • Satish S. Poojary, Maryam Ghufran, Ananya Choudhary, Mehreen Aftab
    Pages 55-63

  7. Role of Autophagy in Cancer Cell Metabolism

    • Diego A. Pedroza, Vaishali Chandel, Dhruv Kumar, Prakash Doddapattar, M. S. Biradar, Rajkumar Lakshmanaswamy et al.
    Pages 65-87

  8. Role of c-Met/HGF Axis in Altered Cancer Metabolism

    • Vaishali Chandel, Sibi Raj, Ramesh Choudhari, Dhruv Kumar
    Pages 89-102

  9. Recent Advances in Drug Development Targeting Cancer Metabolism

    • Narayan Sugandha, Lovika Mittal, Amit Awasthi, Shailendra Asthana
    Pages 103-126

  10. Clinical Relevance of “Biomarkers” in Cancer Metabolism

    • Niraj Kumar Jha, Saurabh Kumar Jha, Ankur Sharma, Rahul Yadav, Pratibha Pandey, Kavindra Kumar Kesari et al.
    Pages 127-146

  11. Alterations in Metabolite-Driven Gene Regulation in Cancer Metabolism

    • Saurabh Kumar Jha, Rahul Yadav, Kumari Swati, Niraj Kumar Jha, Ankur Sharma, Fahad Khan et al.
    Pages 147-165

  12. Role of Phytochemicals in Cancer Cell Metabolism Regulation

    • Abhijeet Kumar, Anil Kumar Singh, Mukul Kumar Gautam, Garima Tripathi
    Pages 167-184

  13. Correction to: Cancer Cell Metabolism: A Potential Target for Cancer Therapy

    • Dhruv Kumar
    Pages C1-C1
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Keywords

About this book

This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.

Editors and Affiliations

  • Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, India

    Dhruv Kumar

About the editor

Dr Dhruv Kumar is an Associate Professor at the Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, Uttar Pradesh, India. His current research is focused on cancer cell metabolism, tumour microenvironment, autophagy, exosomes, mutational heterogeneity, cancer prevention, NGS and bioinformatics.


He received his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), Italy under an Indo-Italian Government fellowship in 2012. After completing his Ph.D., he pursued postdoctoral training at the University of Kansas Medical Center, Kansas City, USA. During this training, he worked towards understanding the molecular mechanism(s) of the regulation of autophagy and apoptosis in cancer stem cells (prostate, pancreatic and breast), as well as understanding metabolic crosstalk between the tumour microenvironment (Cancer Associated Fibroblast (CAF)) and Head and Neck Squamous Cell Carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signalling pathways.


He has published several research articles in peer-reviewed international journals including Cancer Research, Scientific Reports, Genes, Radiation Research, Oncogenesis, Oncotarget, Cancer Letters, PlosOne, Pharmacology & Therapeutics, Biochemical Pharmacology etc., and has authored or co-authored numerous books and book chapters. He is a member of many international and national scientific societies and organizations and received several prestigious national and international awards including the Early Career Research Award, SERB, DST-India, K-INBRE Postdoctoral Award, National Institute of General Medical Sciences, National Institute of Health (P20 GM103418), USA, Young Scientist Award, International Academy of Physical Science, Allahabad, India, Brains in Competition Award, Institute of Advance Studies, University of Bologna, Italy, and the Indo-Italian Government Scholarship Award (Ministry of Human Resource and Development), India.

Bibliographic Information

  • Book Title: Cancer Cell Metabolism: A Potential Target for Cancer Therapy

  • Editors: Dhruv Kumar

  • DOI: https://doi.org/10.1007/978-981-15-1991-8

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2020

  • Hardcover ISBN: 978-981-15-1990-1Published: 14 February 2020

  • Softcover ISBN: 978-981-15-1993-2Published: 14 February 2021

  • eBook ISBN: 978-981-15-1991-8Published: 13 February 2020

  • Edition Number: 1

  • Number of Pages: XIII, 184

  • Number of Illustrations: 7 b/w illustrations, 22 illustrations in colour

  • Topics: Cancer Research, Molecular Medicine, Oncology

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