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Peroxisomes: Biogenesis, Function, and Role in Human Disease

  • Book
  • © 2019

Overview

Editors:
  1. Tsuneo Imanaka

    1. Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, Japan, University of Toyama, Toyama, Japan

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  2. Nobuyuki Shimozawa

    1. Division of Genomics Research, Life Science Research Center, Gifu University, Gifu, Japan, Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan

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  • Describes our current understanding of the biogenesis and function of peroxisomes

  • Examines the role of peroxisomes in human diseases and the latest diagnostic and therapeutic strategies

  • Discusses a range of hot topics in peroxisome research

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Biogenesis and Function of Peroxisome

    1. Front Matter

      Pages 1-1
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    2. The History of Peroxisomal Research

      • Tsuneo Imanaka
      Pages 3-13

    3. Peroxisome Biogenesis

      • Kosuke Kawaguchi, Tsuneo Imanaka
      Pages 15-42

    4. Peroxisome Degradation and Its Molecular Machinery

      • Masahide Oku, Yasuyoshi Sakai
      Pages 43-58

    5. The Function of the Peroxisome

      • Masashi Morita, Tsuneo Imanaka
      Pages 59-104

  3. Dysfunction of Peroxisome and Human Disease

    1. Front Matter

      Pages 105-105
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    2. Peroxisomal Disorders

      • Nobuyuki Shimozawa
      Pages 107-136

    3. Model Organisms for Understanding Peroxisomal Disorders

      • Shigeo Takashima, Nobuyuki Shimozawa
      Pages 137-157

    4. Diagnosis of Peroxisomal Disorders

      • Nobuyuki Shimozawa
      Pages 159-169

    5. Therapeutic Strategies for X-Linked Adrenoleukodystrophy, a Representative Peroxisomal Disorder

      • Masashi Morita
      Pages 171-200

  4. Topics in Peroxisome Research

    1. Front Matter

      Pages 201-201
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    2. The Isolation of Peroxisomes

      • Tsuneo Imanaka
      Pages 203-219

    3. Structure Biology of Peroxisomal Proteins, Peroxins

      • Hiroaki Kato
      Pages 221-248

    4. Lipidomics of Peroxisomal Disorders

      • Kotaro Hama, Yuko Fujiwara, Kazuaki Yokoyama
      Pages 249-260

    5. Neurophysiology and Neuropsychology in Adrenoleukodystrophy (ALD)

      • Makiko Kaga
      Pages 261-279
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Keywords

About this book

This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Editors and Affiliations

  • Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, Japan, University of Toyama, Toyama, Japan

    Tsuneo Imanaka

  • Division of Genomics Research, Life Science Research Center, Gifu University, Gifu, Japan, Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan

    Nobuyuki Shimozawa

About the editors

Tsuneo Imanka, Faculty of Pharmaceutical Sciences, Hiroshima International University, JapanNobuyuki Shimozawa, Division of Genomics Research, Life Science Research Center, Gifu University, Japan

Bibliographic Information

  • Book Title: Peroxisomes: Biogenesis, Function, and Role in Human Disease

  • Editors: Tsuneo Imanaka, Nobuyuki Shimozawa

  • DOI: https://doi.org/10.1007/978-981-15-1169-1

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-15-1168-4Published: 17 January 2020

  • Softcover ISBN: 978-981-15-1171-4Published: 17 January 2021

  • eBook ISBN: 978-981-15-1169-1Published: 16 January 2020

  • Edition Number: 1

  • Number of Pages: XII, 279

  • Number of Illustrations: 32 b/w illustrations, 33 illustrations in colour

  • Topics: Human Physiology, Cell Biology, Cell Physiology, Animal Biochemistry

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